Exam 2

Question 1

Concerning monoclonal antibodies (MAbs), which of the following statements is NOT true?
-Examples include Humira®, Herceptin® and Avastin®.
- MAbs are glycoproteins with high beta-sheet content.
- Antigen binding occurs through the constant domain rather than the variable domain.
- The molecular weight of an intact MAb is ~150,000 daltons.
- MAbs are comprised of light and heavy chains.

Answer 1

• Antigen binding occurs through the constant domain rather than the variable domain.