Exam 2 Flashcards
Synarthroses
Immovable Joint
Ampiarthroses
Semi-movable joint
Diarthroses/Synovial
Freely movable joint
Where are synovial joints located?
At the end of long bones such as femurs, tibias, humerus, and radius
Articular capsule
Joint capsule that surrounds synovial joints
What are synovial joints composed of ?
Synovial membrane, synovial fluid, and articular cartilage
Meniscus
Accessory structure of the knee joint
Functions of synovial fluid
Lubrication, nutrient distribution, and shock absorption
Functions of articular cartilage
Covers articulating surfaces and prevents direct contact between bones
Types of intervertebral joints
First two cervical vertebrae are joined by a synovial joint
Synovial joints lie between adjacent processes
Adjacent vertebral bodies form symphyses
Structure of anulus fibrosus
Tough outer layer of fibrocartilage
Function of anulus fibrosus
Attaches disc to vertebrae
Structure of nucleus pulposus
Elastic, gelatinous core
Function of nucleus pulposus
Absorbs shocks
Buldging discs
Bulge in anulus fibrosus that invades vertebral canal
Herniated discs
Nucleus pulposes breaks through anulus fibrosus and compresses spinal nerves
Location of ACL
Anterior tibia to posterior femur
Function of ACL
Keeps the tibia from moving forward
Location of PCL
Posterior tibia to anterior femur
Function of PCL
Keeps tibia from moving back
Which ligaments stabilize the knee joint?
Tibia collateral ligament (ACL) and fibular collateral ligament (MCL)
Classifications of menisci
Medial and lateral
What are the muscles of the rotator cuff?
Supraspinatus, infraspinatus, teres minor, subscapularis
What is arthritis?
All rheumatic diseases that affect synovial joints
Osteoarthritis
Caused by mechanical stresses of the joint surfaces
Rheumatoid arthritis
Immune system attacks joint tissue
Gouty arthritis
Crystals of uric acid form within synovial fluid
Neurons
Brain cell that sends an electrical impulse in one direction
Most common neuron?
Multipolar neuron
Pathway of an electrical impulse
Presynaptic cell -> synapse -> postsynaptic neuron
Location of neuroglia
Central nervous system and peripheral nervous system
Contents of central nervous system
Astrocytes, ependymal, oligodendrocytes, and microglia
Astrocytes
Maintain blood brain barrier, provides structural support, regulate ion, nutrient, and dissolved gas concentrations, absorb and recycle neurotransmitters, form scar tissue after injury
Ependymal cells
Line ventricles (brain) and central canal (spinal cord), assist in producing, circulating, and monitoring cerebrospinal fluid.
Oligodendrocytes
Myelinate central nervous system axons and provide structural framework
Microglia
Remove cell debris, waste, and pathogens by phagocytoses
Contents of the peripheral nervous system
Satellite cell and Schwann cells
Satellite cells
Surround neuron cell bodies in ganglia, regulate O2, CO2, nutrient, and neurotransmitter levels around neurons in ganglia
Schwann cells
Surround all axons in peripheral nervous system, responsible for myelination of peripheral axons, participate in repair process after injury
Location of CNS
Brain and spinal cord
Location of PNS
Nervous tissue outside of the CNS and ENS
Chemically gated ion channel
Opens in presence of ligand at a binding site
Voltage-gated ion channel
Opens with changes in membrane potential (-60 mV)
Mechanically gated ion channel
Opens in response to the distortion of the membrane
Polarization
Neuronal polarization establishes distinct molecular structures to generate a single axon and multiple dendrites.
Depolarization
An all-or-nothing event that is initiated by the opening of sodium ion channels within the plasma membrane. +30mV
Hyperpolarization
When the membrane potential becomes more negative at a particular spot on the neuron’s membrane
Graded potential vs action potential
The main difference between graded potential and action potential is that graded potentials are the variable-strength signals that can be transmitted over short distances whereas action potentials are large depolarizations that can be transmitted over long distances
What is the treshold?
The critical level to which a membrane potential must be depolarized to initiate an action potential. -55mV
Function of a dendrite
Recieves information
Cell body of a neuron
Processes and integrates information
Function of an axon
Carries the information along long distances
Function of an axon terminal
Transmits information to next cell in the chain
Where does continuous propagation occur?
Unmyelinated axons
Where does salutatory propagation occur?
Myelinated axons
How does myelin affect action potential?
Myelin makes it go faster
Where are the checkpoints?
Oligodendrocytes and Schwann cells
Size of type A fibers
Large diameters
Myelination status of type A fibers
Myelinated
Relative speed of type A fibers
Fast
Size of type B fibers
Small diameter
Myelination status of type B fibers
Myelinated
Relative speed of type B fibers
Medium
Size of type C fibers
Small diameter
Myelination status of type C fibers
Unmyelinated
Relative speed of type C fibers
Slow
Inhibitory neurotransmitters
Decreases the likelihood that the neuron will fire an action potential (GABA)
Excitatory neurotransmitters
Increases the likelihood that the neuron will fire an action potential (Glutamate)
What happens when acetyl choline is blocked?
Paralysis occurs
Types of spinal nerves
Cervical nerves, thoracic nerves, lumbar nerves, sacral nerves, and coccygeal nerves
Conus Medullaris
The tip of the spinal cord
Cauda Equina
Collection of spinal nerve roots coming off of the conus medullaris
What are the functional organs of grey matter?
Sensory nuclei and motor nuclei
Horns of grey matter
Posterior, lateral, and anterior
Layers of the spinal meninges
Dura, arachnoid, subarachnoid, and pia mater
Which layer of the meninges touches the brain?
Pia mater
What is subarachnoid space?
Filled with cerebral spinal fluid and blood vessels; extends down to filum terminale
Somatic motor neurons
Skeletal muscles
Autonomic motor neurons
Smooth muscles, cardiac muscles, glands, and adipose tissue
Somatic sensory neurons
Monitor the outside world and our position within it
Visceral sensory neurons
Monitor internal conditions (organs)
Describe pain fibers
Small, slow, and unmyelinated
Reflex arc
Sensory neurons sends information in
Describe the stretch reflex
Monosynaptic, fastest motor responses, automatic regulations of muscle length
Polysynaptic neurons
Correct neuron is fired while alternate is shut down
Antagonist muscle
Muscle working against muscle of interest
What are neurotransmitters?
Chemicals
Withdrawal reflex
Releasing acetyl choline to contract muscle, polysynaptic, multiple muscle groups (Flexor reflex)
Crossed extensor reflex
Polysynaptic, multiple muscle groups, and contralateral reflex arc (affects other side of the body)
Regions of the brain
Cerebrum, cerebellum, and brainstem
Functions of the cerebrum
Conscious thought processes, intellectual functions, memory storage/processing
Conscious and subconscious regulation of skeletal muscle contractions
Functions of the thalamus
Relays and processes sensory information
Function of the hypothalamus
Controls emotions, regulates body temp, coordinates voluntary and autonomic functions, behavioral drives, and hormone production
Function of the pons
Relays sensory information to the cerebellum and thalamus
Subconscious somatic and visceral motor sensors
Function of the medulla oblongata
Relays sensory information to the thalamus to other portions of the brain stem
Autonomic centers for regulation of visceral function
Longitudal cerebral fissue
Separates cerebral hemispheres
What is gyri?
Squiggly worm like structure to increase surface areas
Somatosensory information
Sensory information from the body
What does the primary motor cortex control?
Voluntary control of the skeletal muscles (Frontal lobe)
What does the primary somatosensory cortex control?
Conscious perception of touch, pressure, pain, vibration, taste, and temperature (Parietal lobe)
What does the visual cortex control?
Conscious perception of visual stimuli (Occipital lobe)
What do the auditory cortex and olfactory cortex control?
Conscious perception of auditory and olfactory stimuli (Temporal lobe)
What do all lobes work together to do?
Integration and processing of sensory data; processing and initiation of motor activities
Fibers of the white matter of the cerebrum
Association fibers, arcuate fibers, and longitudinal fasciculi
Function of the association fibers
Interconnect cortical areas within the same hemisphere
Functions of the arcuate fibers
Interconnect gyri within a lobe
Functions of the longitudinal fasciculi
Interconnect the frontal lobe with other cerebral lobes
Function of the commissures
Interconnect and permit communication between the cerebral hemispheres
Types of commissures
Corpus callosum and anterior commisure
Function of projection fibers
Connect cerebral cortex to diencephalon, brainstem, cerebellum, and spinal cord
Association areas
Interpret information from primary cortices
Relaying center of the brain
Thalamus
Gustatory cortex
Processes taste
Function of the prefrontal cortex
Coordinates information relayed from all cortical association areas and performs abstract intellectual functions
Lobotomy
what i need
Hemispheric lateralization
Functional differences between left and right cerebral hemispheres
Optic chiasm
Stuff erased by vision
Wernickes area
Language comprehension and left cerebral hemisphere. Association area towards the back of the game
Broca’s area
Controls speech production, primarily associated with left cerebral hemisphere, regulates patterns of breathing and vocalization. Towards the front of the brain
What are the ventricular systems of the brain?
Lateral ventricles, interventricular foramen, third ventricle, cerebral aqueduct, and fourth ventricle
Function of the cerebrospinal fluid
Support brain, cushion delicate neural structures, transport nutrients, chemical messengers, and wastes
How does CSF help in terms of head trauma?
Cushions brains against sudden jolts
How do dura folds protect the brain?
It holds the brain in position and protect it from damage resulting from contact with the cranium
What are tight junctions?
Proteins that act as a staple. Present in all epithelial cells.
How is the blood CSF barrier formed?
Ependymal cells connected by tight junctions
What is the function of the blood CSF barrier?
Limits transfer of substances to CSF
What is the function of the blood brain barrier?
Isolates CNS from general circulation
What is the BBB composed of?
Network of tight junctions
How to astrocytes regulate BBB?
Releasing chemicals that control the permeability of endothelium
What is the limbic system?
The emotional system. Emotions are composed of both thought and physical response
Function of the limbic system?
Establishes emotional states, facilitates memory storage and retrieval.
What emotion is associated with the amygdaloid body?
Fear
Basal nuceli
Subconscious control of skeletal muscle tone, coordination of learned movement patterns.
Basal ganglia
“Trims the fat on your movements”
What causes the symptoms of parkinson’s disease?
Increased activity of basal nuclei
What is the function of the caudate nucleus?
Subconscious adjustment and modification of voluntary motor commands
What is the function of lentiform nucleus?
Subconscious adjustment and modification of voluntary motor commands.
What are the components of the Lentiform nucleus?
Putamen and globus pallidus
What is cranial nerve I and what is its function?
Olfactory: controls sense of smell from nose (S)
What is cranial nerve II and what is its function?
Optic Nerve: Controls vision (S)
What is cranial nerve III and what is its function?
Oculomotor nerve: supplies the muscles of the eyes (M)
What is cranial nerve IV and what is its function?
Trochlear nerve: serves the superior oblique eye muscle (M)
What is cranial nerve V and what is its function?
Trigeminal nerve: Sensory from face and mouth, motor to muscles of chewing (B)
What is cranial nerve VI and what is its function?
Abducens nerve: Serves the lateral rectus muscle (M)
What is cranial nerve VII and what is its function?
Facial nerve: serves the muscles responsible for facial expressions as well as the lacrimal and salivary glands (B)
What is cranial nerve VIII and what is its function?
Vestibulochochlear nerve: responsible for maintaining ear equilibrium and hearing (S)
What is cranial nerve IX and what is its function?
Glossopharyngeal nerve: helps the pharynx in swallowing (B)
What is cranial nerve X and what is its function?
Vagus nerve: Allows sensations from visceral organs and aids in parasympathetic motor regulation of visceral organs. (B)
What is cranial nerve XI and what is its function?
Accessory nerve: muscles that move the neck, head, and shoulders (M)
What is cranial nerve XII and what is its function?
Hypoglossal nerve: Serves muscles of the tongue (M)
What is sensation?
Arriving information
What is perception?
Conscious awareness of a sensation
Receptor specificity?
Each receptor has a characteristic sensitivity
Receptor field?
Area monitored by a single receptor cell
Transduction?
Conversion of an arriving stimulus into an action potential by sensory receptor
What is a dermatone?
Area covered by the anterior root
Somatic sensory pathway
Carries sensory information from skin and muscles of the body wall to CNS
What are the major somatic sensory pathways?
Spinothalamic pathway, posteior column pathway, spinocerebellar pathway
Visceral sensory pathways
Interoreceptors in visceral tissues and organs
Nociceptors
Pain
Thermoreceptors
Temperature
Mechanoreceptors
Physical distortion
Chemoreceptors
Chemical concentration
Fibers of nociceptors
Myelinated type A fibers (sharp pain) and unmyelinated type C fibers (slow pain)
Pathway of mechanoreceptors
Physical stimuli -> distort plasma membrane -> mechanically gated ion channel
Classes of mechanorecptors
Tactile receptors, baroreceptors, and propioceptors (joints and skeletal muscles)
Root hair plexus
A root hair plexus is made up of free nerve endings stimulated by hair movements
Free nerve endings
Branching tips of sensory neurons that respond to touch, pain, pressure, and temperature.
Tactile discs
Fine touch and pressure receptors sensitive to shape and texture
Baroreceptors of carotid sinus and aortic sinus
Changes in BP
Baroreceptors of lung
Tells you pressure of lungs to determine breathing rate
Baroreceptors of digestive tract
When you’re full or need to poop
Baroreceptors of bladder wall
When you have to pee
Proprioception
A somatic sensation (know your arm is bent while your eyes are closed)
Where are proprioreceptors found?
Joints, tendons, ligaments, and muscles
What are the major groups of proprioreceptors?
Muscle spindles, golgi tendon organs, and receptors in joint capsules.
Function of muscle spindles?
Monitor skeletal muscle length and trigger stretch reflex
Function of golgi tendon organs?
Monitor tension during muscle contraction
Function of receptors in joint capsules?
Nerve endings that detect pressure, tension, and movement at the joint.
Function of chemoreceptors
Monitor pH, CO2, and O2 levels
First order neurons
Sensory neuron that delivers sensations to CNS
Second-order neurons
Interneuron in spinal cord or brainstem that receives information from FON
Decussation
Crosses to opposite side of CNS
Third-order neurons
Neurons in thalamus that must receive information from SON. Needs to pass third-order neurons to reach awareness.
How many neurons does the spinothalamic pathway use?
3
Where is the synapse in the spinothalamic pathway?
Posterior horns
What does the anterior spinothalamic tract sense?
Crude touch and pressure sensations
What does the poterior column pathway do?
Carries sensation of fine touch, vibration, pressure, and proprioception
What does the lateral spinothalamic tract sense?
Pain and temperature
Where is the posterior column pathway processed?
Thalamus
Different types of humunculus
Sensory and motor
Function of the posterior column pathway
Determines how a sensation is perceieved
What is the sensory humunculus?
Functional map of the primary somatosensory cortex
Spinocerebellar pathway
Position of skeletal muscles, tendons, and joints and goes to the cerebellum
Somatic nervous system
Controls contractions of the skeletal muscles
Somatic motor pathways
Always involve at least two motor neurons
Upper motor neuron path
Brain to the spinal cord, cell body lies in a CNS processing center, synapses on lower motor neuron (in the spinal cord), facilitates or inhibits the lower motor neuron
Lower motor neuron
Spinal cord to the muscles, cell body in brainstem or spinal cord (only the axon extends outside the CNS), Innervates a single motor unit in skeletal muscle, triggers a contraction in innervated muscle, damage eliminates voluntary and reflex control over innervated motor unit (face droops)
How do conscious and subconscious motor commands control skeletal muscles?
Travels over corticospinal pathways, medial pathways, and lateral pathways
Function of the corticospinal pathways?
Provides voluntary controls over skeletal muscles
Corticospinal tracts
Axons synapse on lower motor neurons in anterior horns of spinal cord
Function of the medial pathway?
Helps control gross movements of trunk and proximal limb muscles (walking) Maintain posture and balance
Function of the lateral pathway?
Helps control distal movements (writing)
Where does the medial pathway recieve information from?
Vestibulocochlear nerve
Components of medial pathway
Superior colliculi and inferior colliculi
Superior colliculi
Visual sensation
Inferior colliculi
Auditory sensation
What does the the medial pathway form?
Reticular formation (staying awake)
What is the basal pathway and cerebellum responsible for?
Coordination and feedback control over muscle contractions