Exam # 1 OB Review Flashcards
Which 3 auxiliary structures develop simultaneously with fetal growth to sustain the pregnancy and permit normal prenatal development?
1) Placenta
2) Umbilical Cord
3) Fetal Membranes
What are the 3 functions of the placenta?
1) Metabolic
2) Endocrine
3) Transfer of substances between mother and fetus
Te placenta produces some nutrients needed for the embryo and for its own functions. What are some of the substances synthesized?
1) Glycogen
2) Cholesterol
3) Fatty Acids
PO2 of maternal blood in the intervillous space is 50mm Hg while the average blood PO2 in the umbilical vein (after oxygenation) is about 30 mm Hg. Name 3 reasons why the fetus can thrive in this low-oxygen environment.
1) Fetal hemoglobin can carry 20% to 50 % more oxygen than adult hemoglobin.
2) The fetus has a higher oxygen carrying capacity because of a higher average hemoglobin (15 to 24 g/dL) and hematocrit value (44% to 70%).
3) Bohr Effect - Hemoglobin can carry more oxygen at low PCO2 levels than it can at high ones.
IGg maternal antibodies can be transferred to the fetus to provide temporary (passive) immunity against what types of diseases?
1) Rubella*
2) Tetanus*
* Only if the mother is immune
Give an example of when maternal antibodies can be harmful to the fetus.
If maternal and fetal ABO blood types of Rh factors are not compatible, the mother may already have or may produce antibodies against fetal RBCs. The mother’s antibodies then may destroy the fetal RBCs, causing fetal anemia or death.
What role do the following hormones play during pregnancy?
1) Estrogen
2) Progesterone
1) Estrogen - Causes enlargement of the uterus, enlargement of the breasts, growth of the ductal systems of the breasts, and enlargement of the external genitalia.
2) Progesterone - Changes endometrium into decidua, reduces uterine contraction, and suppresses maternal reactions to fetal antigens to prevent spontaneous abortion.
What are the two fetal membranes (aka bag of waters), which hold the amniotic fluid, called?
1) Amnion - Inner membrane
2) Chorion - Outer membrane
What is the normal range of volume of amniotic fluid at term? Define Oligohydraminos and Polyhydraminos.
1) Normal Range @ Term - 500 to 1000 mL
2) Oligohydraminos - Less than 500 mL of amniotic fluid @ term.
3) Polyhydraminos (aka hydraminos) - More than 2000 mL of amniotic fluid @ term.
What are the possible causes of Oligohydraminos and what are the fetal implications of this condition?
1) Caused by - Failure of kidneys to develop, fetal urine excretion is blocked, or placental blood flow is inadequate.
2) Fetal Implications - Poor fetal lung development and malformations that result from compression of fetal parts.
What are the possible causes of Polyhydraminos?
Caused by fetal CNS or GI tract abnormalities that prevent the normal fetal cycle involving ingestion of amniotic fluid.
Name and describe the 3 shunts in the fetal circulation.
1) Ductus Venosis - From placenta to Inferior vena cava. It bypasses the fetal liver and goes to the right atrium.
2) Foramen Ovale - From right atrium to left atrium. It bypasses fetal lungs.
3) Ductus Arteriosus - From the pulmonary artery to the pulmonary vein. It bypasses the lungs as well.
Explain Nägele’s Rule as it is used to calculate a woman’s EDD?
For example - LNMP = October 30, 2012
Nägele’s Rule - Subtract 3 months from the 1st day of the LNMP, add 7 days, and correct the year if appropriate.
For example - LNMP = October 30, 2012
Subtract 3 months = July 30, 2012
Add 7 days and correct year = August 6, 2013
What is the normal range for the fetal heart rate?
110 to 160 beats per minute
How can you distinguish the fetal side of the placenta from the maternal side?
1) Fetal Side - Shiny and smooth in appearance, attached to the amniotic sac.
2) Maternal side - Dark red and rough in appearance.
What complications are common with placentas that have accessory lobes and placentas with velamentous insertion of the umbilical cord?
1) Accessory Lobe - Lobe could break off.
2) Velamentous Insertion - Sometimes does not have enough Wharton’s jelly and could rupture. Also, fetal umbilical vessels may be torn, and the fetus can hemorrhage.
What is the term for the two sections (segments) that the placenta is divided into?
Cotyledons
Describe the effects of Cold Stress on the infant.
1) NST - Metabolism of brown fat. This leads to ⬆ production of free fatty acids, which can lead to metabolic acidosis or jaundice.
2) ⬆ Metabolic Rate - Leads to ⬆ use of glucose and ⬇ production of surfactant. This can lead to hypoglycemia and respiratory distress.
3) Vasoconstriction - Leads to pale, mottled skin and shutdown of pulmonary vessels. This can lead to respiratory distress.
What temperature range provides a thermoneutral zone for the healthy, unclothed, full-term newborn?
1) Unclothed - 32 C to 33.5 C ( 89.6 F to 92.3 F)
2) Clothed - 24 C to 27 C (75.2 F to 80.6 F)
What are the normal ranges for the following lab values in the newborn infant?
1) RBCs
2) Hemoglobin
3) Hematocrit
4) WBCs
1) RBCS - 4.8 to 7.1 million/mm3
2) Hemoglobin - 15 to 24 g/dL
3) Hematocrit - 44% to 70%
4) WBCs - 9,000 to 30,000/mm3 at birth (12,000/mm3 by 4 to 5 days after birth).
If an ⬆ in WBCs in the newborn does not necessarily indicate an infection, how can you assess for infection?
An increase in immature WBCs (bands) indicates infection in newborns.
During which weeks of gestation is brown fat developed?
Between weeks 32 and 34
At what serum level does jaundice become visible?
5mg/dL to 6mg/dL
What is the normal range of specific gravity and normal urine output for a newborn?
1) Specific Gravity - 1.002 to 1.01
2) Urine Output - 2 to 5 mL/Kg/Hr