Exam 1- Intro drugs and targets Flashcards
monoclonal antibody that binds TNF and is used in arthritis
infliximab
inhibits cyclooxygenase
aspirin
inhibits dihydrofolate reductase- antineoplastic
methotrexate
inhibits monoamine oxidase; antidepressant
tranylcypromine
activates guanylate cyclase; for treating angina (vasodilator)
nitroglycerin
activates antithrombin 3; anticoagulant
heparin
binds to and inactivates a protein kinase; treatment of leukemia
imitinib
inhibits NE reuptake by neuron
cocaine
diuretic inhibits transport of Na+, Cl- by kidney tubule
chlorothiazide
inhibits serotonin reuptake; antidepressant
fluoxetine
inhibits H+ ion transport by parietal cells and decreases stomach acid
omeprazole
calcium channel blocker; antihypertensive
nifedipine
increases K+uptake; antihypertensive
minoxidil
inhibits Na+ channels
procaine
blocks B adrenergic receptors; antihypertensive
propranolol
blocks histamine H2 receptors; decreases stomach acid
cimetidine
blocks alpha receptors in blood vessels; antihypertensive
prazosin
activates opiate receptors
morphine
activates insulin receptors
insulin
agents that act on intracellular receptors
steroids- glucocorticoids - cortisol
very rapid desensitization is called
tachyphylaxis
