Exam 1- Intro drugs and targets

Question 1

monoclonal antibody that binds TNF and is used in arthritis

Answer 1

infliximab

Question 2

inhibits cyclooxygenase

Answer 2

aspirin

Question 3

inhibits dihydrofolate reductase- antineoplastic

Answer 3

methotrexate

Question 4

inhibits monoamine oxidase; antidepressant

Answer 4

tranylcypromine

Question 5

activates guanylate cyclase; for treating angina (vasodilator)

Answer 5

nitroglycerin

Question 6

activates antithrombin 3; anticoagulant

Answer 6

heparin

Question 7

binds to and inactivates a protein kinase; treatment of leukemia

Answer 7

imitinib

Question 8

inhibits NE reuptake by neuron

Answer 8

cocaine

Question 9

diuretic inhibits transport of Na+, Cl- by kidney tubule

Answer 9

chlorothiazide

Question 10

inhibits serotonin reuptake; antidepressant

Answer 10

fluoxetine

Question 11

inhibits H+ ion transport by parietal cells and decreases stomach acid

Answer 11

omeprazole

Question 12

calcium channel blocker; antihypertensive

Answer 12

nifedipine

Question 13

increases K+uptake; antihypertensive

Answer 13

minoxidil

Question 14

inhibits Na+ channels

Answer 14

procaine

Question 15

blocks B adrenergic receptors; antihypertensive

Answer 15

propranolol

Question 16

blocks histamine H2 receptors; decreases stomach acid

Answer 16

cimetidine

Question 17

blocks alpha receptors in blood vessels; antihypertensive

Answer 17

prazosin

Question 18

activates opiate receptors

Answer 18

morphine

Question 19

activates insulin receptors

Answer 19

insulin

Question 20

agents that act on intracellular receptors

Answer 20

steroids- glucocorticoids - cortisol

Question 21

very rapid desensitization is called

Answer 21

tachyphylaxis