Exam 1 Ch 35 Agents Used in Dyslipidemia Flashcards
Define dyslipidemia.
- elevated total cholesterol, LDL-C or triglycerides
- low HDL-C
- or a combination of both of these
Hyperlipidemia may lead to…
acute pancreatitis or atherosclerosis.
What type of antihyperlipidemics do statins fall under?
HMG-CoA reductase inhibitors
What drugs are most effective in reducing LDLs?
Statins
- structural analogs of HMG-CoA
- competitive inhibitors of HMG-CoA reductase
Which statins are the fluorine-containing cogeners?
atorvastatin, fluvastatin & rosuvastatin
What are lovastatin & simvastatin hydrolyzed to in the GI tract?
Active beta hydroxyl derivatives
What statin is almost completely absorbed?
Fluvastatin
What is the function of fibrates?
To regulate lipid metabolism
Fibrates increase in biliary cholesterol excretion can lead to what?
Lithiasis (gallstones)
What are the 5 classifications of antihyperlipidemics used in dyslipidemia?
Bile Acid Sequestrants Nicotinic Acid HMG-CoA Reductase Inhibitors Fibric Acid Derivatives Cholesterol Absorption Blockers
Which antihyperlipidemic category does ezetimibe belong to?
Cholesterol Absorption Blockers
What are the two fibric acid derivatives of antihyperlipidemics?
Gemfibrozil
Fenofibrate
What are the HMG-CoA Reductase Inhibitors? (7)
Lovastatin Simvastatin Pravastatin Fluvastatin Atrovastatin Rosuvastatin Pitavastatin
Which antihyperlipidemic category does niacin belong to?
Nicotinic Acid
What are the Bile acid sequestrants? (3)
Cholestyramine
Colestipol
Colesevelam
