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Drug Delivery II > Exam 1 Capsules > Flashcards

Exam 1 Capsules Flashcards

1
Q

Advantages of hard gelatin capsules

A

Tasteless
Easier to swallow for some
Easily filled

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2
Q

What percent is the percentage of the amount of compressed tablets produced by the pharmaceutical industry?

A

75% compressed tablets

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3
Q

What is the highest percent of preferred delivery vehicle based on consumer preference?

A

44.2% soft elastic capsules

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4
Q

Primary material for capsule manufacturing?

A

Gelatin

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5
Q

USP allows the inclusion of 0.15% ______ ______ to prevent decomposition during manufacturing

A

Sulfur dioxide

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6
Q

True of False: Gelatin capsules do not protect hygroscopic substance from humidity

A

True because moisture can diffuse through the shell wall

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7
Q

How is the gelatin used in capsules obtained?

A

By hydrolyzing collagenous material

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8
Q

What type of gelatin is derived mainly from porcine skin by acid processing?

A

Type A

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9
Q

What type of gelatin is obtained from bones and animal skin by alkaline processing?

A

Type B

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10
Q

True or False: Better capsules are made using one type of gelatin for uniformity in the structure of the shell

A

False: Blends of both types are used to obtain desirable characteristics in the capsule

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11
Q

When manufacturing capsules, variation in _________ results in thicker or thinner capsule walls. This can cause the two halves to be either too tight or too loose when put together

A

Viscosity

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12
Q

What is the smallest size of capsules?

A

5

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13
Q

What is the largest size of capsules?

A

000

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14
Q

Mixtures that must be mixed with a suitable absorbent such as magnesium carbonate before filling

A

Eutectic

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15
Q

______ and ______ do not pack well in capsules

A

Granules and crystals

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16
Q

How are two incompatible drugs packaged together?

A

One drug is filled in a smaller capsule, that is placed inside a larger capsule containing the other drug

17
Q

True or False: The weight of each capsule must be checked

A

True

18
Q

True or False: Disintegration tests are not required for enteric coated capsules

A

True

19
Q

Lansoprazole Delayed-Release capsules must have no more than ____% of label disintegrate in _____ minutes during the acid stage

A

10% in 60 minutes

20
Q

Lansoprazole Delayed-Release capsules must have not less than ____% disintegrate in ____ minutes during the buffer stage

A

80% in 60

21
Q

Soft elastic capsules (SECapsules) are made of gelatin that are slightly (thinner / thicker) than hard gelatin capsules

A

Thicker

22
Q

Gelatin is made flexible (plasticized) by the addition of ______, ______, or a similar polyol

A

Glycerin, sorbitol

23
Q

True or False: For formulations with an oily vehicle, SECapsules are a convenient dosage form that can be filled with liquid, paste, or powder

A

True

24
Q

True or False: SECapsules are produced in a wide variety of shapes, while hard gelatin capsules are generally strictly oval

A

True

25
Q

Oral SECapsules are generally made so that the seam of the shell opens to release the medication in the stomach with _____ minutes after ingestion

A

5 minutes

26
Q

Most commonly used polymer in vegetable capsules

A

Hypromellose (HPMC)

27
Q

What are the main advantages of HPMC capsules?

A

Less water than gelatin capsules, so better choice for hygroscopic drugs
Dissolution time does not change under stressful storage conditions

28
Q

What are two factors that influence dissolution behaviors of HPMC capsules

A

pH and ionic strength (amount of salts)

29
Q

What can be used in adjunct with HPMC capsules to negate the effects of pH and ionic strength on the dissolution profiles?

A

Gelling aids (carrageenan, gellan, gum, or pectin)

Drug Delivery II (10 decks)

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