Exam 1 Flashcards
fibroblasts
- in tendon, ligament, skin, bone
- creates mostly type I collagen
chondroblasts
- in cartilage
- produces mostly type II
Osteoblasts
- found in bone
- produces type I collagen and
what forms periarticular connective tissues:
- fibrous proteins: collagen, elastin
- ground substance: glycosaminoglycans (GAG), water, solutes
- cells: fibroblasts, chondrocytes
difference between collagen and elastin?
Collagen triple helix
Elastin: net like, no helix, has more give than collagen
Type I collagen
- thick fibers that elongate little when stretched
- comprise ligaments, tendons, fascia, fibrous joint capsules
Type II collagen
- thinner fibers
- framework for maintaining general shape and consistency of structures
- hyaline cartilage
dense connective tissues
- abundant type I collagen
- limited blood supply
- low PG’s/Elastin/cells so low metabolism
acute trauma happens mostly to which joints?
-joints with longest bones since they form longest external moment arms
chronic trauma
- overuse, damage over time
- instability = abnormal loading
- loss of proteins, GAG, water
joint pathology from aging
- protein/PG replacement slows
- dissicated ligaments/cartilage don’t slide as well
- tendons become less stiff and can’t produce muscle force
- weaker bones (reduced cell differentiation
How to regenerate tendon/ligament
-cell: fibroblast
-Stimulus: tension along lines of stress
EX: ext knee for MCL
how to regenerate cartilage
cell: chondrocyte
Stimulus: load/unload along with gliding
EX:bike for patellofemoral irriation
how to regenerate muscle
cell: myocyte
Stimulus: tension to cause disruption of myofibrils
EX: take it to the point of microtearing
how to regenerate bone
cell: osteocyte
Stimulus: compression or tension
EX: with rod through bone for fracture, walk on it; compression stimulates new bone matrix
enthesis organ
- reduces tensile load on insertion
- confers a mechanical advantage on muscle-tendon unit
- different tissues with different Youn’s moduli gliding along each other cause inappropriate cell stimulation
mechanotransduction
: how mechanical forces cause protein expression
bone has what type of collagen?
type I
cartilage has what type of collagen?
type II
tissue type of joint capsules
- dense irregular
- stretched in all directions so striations not in same direction
tissue type of tendon/ligament
dense regular
-striate in uniform direction
loose connective tissue
does not have as much collagen
collagen is a ___
protein
Scleraxis Protein
- leads to new tendon building blocks
- turned on by amount of load (in its line of stress)
- imperfect restoration
Tissue make up effected by:
- activity
- inactivity
- age
- trauma
example of a planar joint
- facet joints in vertebral columm
- carpals (hamate and triquetrum)
example of a hinge joint
humeroulnar joint at elbow
example of pivot joint
atlas on dens of axis
example of a saddle joint
thumb carpal to metacarpal joint
example of a condyloid joint
carpal MCP joint
diarthrodial joints
- synovial joints
- freely moveable
- joint cavity separates bones
Layers of synovial joint (superficial to deep)
- ligament
- joint capsule
- fat pad
- synovial membrane
- articular cartilage
- synovial fluid
location of nerves in a synovial joint:
- bone
- articular cartilage
- in outer layer of joint capsule