Exam 1 Flashcards
Chronicity Factor: Definition
ratio between acute LD50 and chronic LD50
Chronicity Factor:
toxicant isn’t cumulative
Chronicity Factor: > 2
toxicant is cumulative
Highest Non-Toxic Dose (HNTD): Definition
highest dose possible w/o undesirable alterations
% -> g/100ml
1% = 1g/100ml
ppm -> mg/kg
1ppm = 1mg/kg
ppm -> %
1 ppm = 0.0001%
ppm -> mg/dL
1ppm = 0.1mg/dL
ppm -> g/ton
1.1ppm = 1g/ton
Dilution Equation
% required/ % of stock x V required
Toxicity Equation
ppm in feed x % of BW eaten daily
What agency performs safety testing?
Environmental Protection Agency
Toxicology Dx: Criteria
history, signs, postmortem finding, lab findings
Toxicology Dx: History
O info, mode of exposure, examine food/water
Toxicology Dx: Clinical Signs
signs, PE
Toxicology Dx: Postmortem Findings
gross and microscopic examination
Toxicology Dx: Lab Findings
clin path tests, chem analysis
Toxicosis: Treatment
symptomatic until toxin is out of the system/removed
Toxicosis: Removal Methods
remove source, remove from site of absorption (wash, v/d), dec. absorption (precipitation, adsorption)
Organophosphate: Purpose
Insecticide
Organophosphates: Properties
bioactivated (lethal synthesis), degrades in 2-4wks in environment, storage activation
Organophosphates: Toxicokinetics
lipophilic - absorbed by GI, skin, mm, and inhalation
distributed throughout the body
Organophosphates: MoA
irreversible inhibition of cholinesterases => muscarinic activation
Organophosphates: Signs
Diarrhea Urination Miosis Bronchoconstriciton Bradychardia Emesis Lacrimation Salivation
Organophosphates: Dx
direct detection, atropine response test (strong response = not OP), history
Organophosphates: Treatment
decontaminate, supportive, atropine, 2-PAM
Carbamates: Purpose
Insecticide
Carbamates: MoA
reversible ACh inhibitor => muscarinic activation
Carbamates: Signs
Diarrhea Urination Miosis Bronchoconstriciton Bradycardia Emesis Lacrimation Salivation
Carbamates: Tx
supportive, atropine
Organochlorines: Purpose
insecticide (DDT)
Organochlorines: Properties
highly lipophilic, 2-15 year environment half-life
Organochlorines: Tk
readily absorbed, well distributed, poss. lethal synthesis, enterohepatic recycling, redistributes to fat
Organochlorines: MoA
slow Na influx and K efflux => repetitive firing of neuron
Organochlorines: Signs
CNS stimulation, ataxia, seizures
Organochlorines: Dx
ID toxin, history
Organochlorines: Tx
decontaminate, symptomatic
Pyrethrins: Purpose
insecticide
Pyrethrins: Properties
unstable in air and light, very toxic to fish and birds
Pyrethrins: Tk
lipophilic, metabolized in GI, plasma, and liver, works better at lower temp.
Pyrethrins: MoA
delay closure of Na ion channels => paralysis
Pyrethrins: Signs
muscle tremors, depression, ataxia, v/d, dyspnea, hyperexcitablility
Pyrethrins: Dx
history, signs
Pyrethrins: Tx
decontaminate, keep warm, symptomatic
Rotenone: Purpose
insecticide
Rotenone: Properties
toxic to fish
Rotenone: Tk
inhalation is more toxic than ingestion, eliminated in feces w/in 24hrs
Rotenone: MoA
blocks oxidative phosphorilation => anesthetic like effects
Rotenone: Signs
irritation, depression, seizures, asphyxia
Rotenone: Dx
lab (hypoglycemia, liver changes, hypoxemia), history
Rotenone: Tx
decontaminate, symptomatic
Nicotine: Purpose
Insecticide (tobaco)
Nicotine: Tk
absorbed well through inhalation and skin, well distributed, alk. stomach inc. absorption, poss. enterohepatic recycling
Nicotine: MoA
nicotinic receptor agonist
Nicotine: Signs
Early - ataxia, hypersalivation, vomiting, bradycardia, tremors;
Later - CNS depression; odor
Nicotine: Dx
ID toxin, history
Nicotine: Tx
decontaminate (w/o alkalizing stomach/urine), enhance excretion, atropine, symptomatic
Amitraz: Purpose
Insecticide
Amitraz: MoA
a-2 agonist
Amitraz: Tk
readily absorbed orally, inhaled, or skin, 24hr elimination half-life, distributed throughout body
Amitraz: Signs
transient sedation (24-72hrs), vomiting
Amitraz: Dx
ID toxin, history, signs
Amitraz: Tx
yohimbine, atipamezole, decontaminate
DEET: Purpose
Insecticide (OFF, Cutter)
DEET: Tk
can persist in skin
DEET: Signs
Small Mammals - depression ataxia, tremors, seizures;
Dogs/cats - hypersalivation, vomiting, tremors, ataxia
DEET: Dx
ID toxin, history, signs
DEET: Tx
decontaminate, symptomatic
Naphthalene: Purpose
insecticide (mothballs
Naphthalene: Tk
absorbed by ingestion, inhalation, or through skin
Naphthalene: MoA
oxidation => methemoglobinemia
Naphthalene: Signs
odor, salivation, v/d, hemolysis, methemoglobinemia (brown mm), secondary hepatic and renal damage
Naphthalene: Dx
hematologic changes, history, signs
Naphthalene: Tx
ascorbic acid (Vit C), decontaminate, symptomatic
Ivermectin: Purpose
insecticide (dewormer)
Ivermectin: Tk
well absorbed orally, well distributed but CNS (except ABCB-1 mutation), excreted unchanged in feces, 2d elimination half-life
Ivermectin: MoA
GABA agonist
Ivermectin: Signs
CNS depression, sedation
Ivermectin: Dx
ID toxin, history, signs
Ivermectin: Tx
decontaminate, symptomatic
Anticoagulant Rodenticides: Properties
odorless, tasteless, wks for environmental breakdown, slow onset
Anticoagulant Rodenticides: Tk
complete absorption, PP bound
Anticoagulant Rodenticides: MoA
inhibit Vit. K conversion
Anticoagulant Rodenticides: Signs
1-5d post exposure, hemorrhage (and associated secondary signs)
Anticoagulant Rodenticides: Dx
hemorrhage lesions, ID toxin, history, signs, blood work (CBC, coag)
Anticoagulant Rodenticides: Tx
Vit. K1 orally
Cholecalciferol: Purpose
rodenticide (quintox, rampage, Vit D cream)
Cholecalciferol: Properties
Vit D3, lipophilic
Cholecalciferol: Tk
absorbed in GI, PP bound, enterohepatic cirulation
Cholecalciferol: MoA
causes hypercalcemia and hyperphosphatemia
Cholecalciferol: Signs
24-36hr post exposure, anorexia, PU/PD, arrhythmias, hypertension, hemorrhagic GI, mineralized soft tissue
Cholecalciferol: Dx
inc. Ca, P, Vit D; dec. PTH, eliminate differentials, hisotry, signs
Cholecalciferol: Tx
decontaminate, symptomatic, hypercalcemia
Bromethalin: Purpose
Rodenticide
Bromethalin: Tk
highly lipophilic, rapidly absorbed orally, widely distributed, 5-6d elimination half-life, enterohepatic recycling
Bromethalin: MoA
uncoupling of oxidative phosphorylation => depletion of ATP
Bromethalin: Signs
Acute (2-24hrs) - CNS excitation, death
Subacute (2-3d) - hind limb ataxia, progress to UMN signs, CNS depression
Bromethalin: Dx
cerebral edema, ID toxin, history, signs
Bromehtalin: Tx
decontamination (activated charcoal w/ sorbitol, symptomatic