Exam 1 Flashcards
quiz 1 plus this
87% of CVAs are due to _____
ischemia
t/f: a patient with a TIA are at increased risk for CVA within 90 days
true
t/f: TIA symptoms resolve within 24 hours
true
t/f: CVA deficits result after 24 hours
true
are patients with atherosclerosis at increased risk of coronary artery disease?
yes
is carotid stenosis more predictive of MI or stroke?
MI
what can carotid duplex ultrasonography identify?
plaque
stenosis
occlusions
how is cerebrovascular disease diagnosed?
CTA (computed tomographic angiography)
MRA (magnetic resonance angiography)
how is cerebrovascular disease medically managed?
decrease risk factors
decrease BP
pharmacological
what are pharmacological ways to manage cerebrovascular disease?
aspirin
anti-coagulation
lipid-lowering
glycemic control
anti-hypertensives
stations
what is renal artery disease?
atherosclerosis of one or both renal arteries
what is the gold standard for diagnosing renal artery disease?
renal angiography
what are the signs of renal artery disease?
HTN
decreased kidney function
edema of the legs, feet, or ankles
darkened skin
weight loss
what are the symptoms of renal artery disease?
increase/decrease in urination
drowsiness/tiredness
generalized itching or numbness
dry skin
headaches
loss of appetite
nausea and vomiting
sleep problems
trouble concentrating
muscle cramps
t/f: sign of renal artery disease are often absent until severe
true
what lab values determine kidney function in people at risk for developing or have known kidney disease?
creatinine and BUN (blood urea nitrogen)
what does creatinine levels show?
direct measurement of glomerular filtration rate and renal function
what does increased creatinine levels indicate?
decreased glomerular filtration rate which indicates renal insufficiency
if glomerular filtration rate decreases, creatinine will ______, indicating ______ ______
increase, renal insufficiency
what level of creatinine indicates serious impairment of renal function?
> 4.0 mg/dL
what are normal creatinine levels?
male: 0.6-1.2 mg/dL
female: 0.5-1.1 mg/dL
what is creatinine?
a catabolic product creatine phosphokinase which is used in skeletal muscle contraction and is excreted entirely by the kidneys
what is BUN?
the nitrogen portion of urea that measures metabolic function of the liver and excretory function of urea
elevated BUN indicates _____ _____ and _____
renal failure, uremia
what could cause decreased BUN?
starvation, dehydration, or organ dysfunction like liver disease
what is renal angiography?
x-ray that shows the blood vessels in the kidneys
why is renal angiography sometimes not the best option for a patient?
the contract used can increase creatinine levels in patients with kidney dysfunction
how is renal artery disease medically managed?
pharmacological
BP control
risk factor modification
surgical management
what are common pharmacologic managements of renal artery disease?
angiotensin-converting enzyme (ACE) inhibitors
angiotensin receptor blockers (ARBs)
diuretics
calcium channel or beta blockers
cholesterol lowering meds
anti-coagulation
what are 2 common surgical treatments of renal artery disease?
angioplasty stenting and endarterectomy/bypass surgery
what is angioplasty and stenting?
using a catheter to place a balloon and stent into an artery to flatten the plaque and keep the artery open
what is an endarterectomy or bypass surgery?
plaques cleaned out of the artery - endarterectomy
using a vein/synthetic tube b/w the kidney and aorta to bypass the occlusion
what can renal artery disease lead to?
increased BP
increased protein levels in urine
decreased kidney function
ankle and foot swelling
what can untreated prolonged renal artery disease lead to?
chronic kidney disease
kidney failure
pulmonary edema
stroke
what is the most common aneurysm?
brain aneurysm
are aortic aneurysms more common in men or women?
men
history of smoking accounts for ___% of cases of aortic aneurysms
75%
what are some causes of aneurysms?
atherosclerosis
PAD
cardiovascular disease
traumatic injuries to arterial wall
tobacco use
vasculitis
what is an aneurysm?
weakness in the arterial wall due to pressure that causes a bulge/ballooning of the wall
what are the changes in body structure and function in aneurysms?
damage to the arterial wall that causes permanent dilation
destruction of elastin in the artery so it can’t go back to normal and stays dilated
loss of smooth muscle cells due to formation of intraluminal thrombus
weakening of the tunica media layer
neutrophils, RBCs, and platelets attach to the thrombus along with fibrinogen and lipoprotein
what are the primary locations for aneurysms?
brain, aorta, abdomen, thorax, and extremities
aneurysms have a dilated arterial wall of more than ____ % normal diameter
50
aneurysms are described by their ____, ______, ______ _____, and ______
location, size, morphological appearance, origin
when is an aneurysm at risk for rupture?
when it increases more than 5 cm
if a cerebral aneurysm ruptures, what does it cause?
a hemorrhagic stroke
t/f: an aortic aneurysm can occur at any segment of the aorta coming off the heart
true
what aneurysm is life-threatening if it ruptures?
abdominal aneurysm
is a thoracic aneurysm above or below the diaphragm?
above the diaphragm
what is the most common peripheral aneurysm?
popliteal
what are the common locations of peripheral aneurysms?
popliteal
femoral
illiac
t/f: peripheral aneurysms are very rare
true
what are pseudoaneurysms?
a breach in the arterial wall causes blood to leak and be contained by the adventitia
what are the signs of an aneurysm?
bruit over the swollen area in the abdomen
pulsating tumor/mass in the abdominal area
pressure on surrounding parts such as low back
poor/absent distal pulses below the level of the aneurysm
what are the symptoms of an aneurysm?
severe chest pain from back to front
LBP
leg pain/claudication
numbness in LEs
excessive fatigue
what is the difference b/w a rupture and a dissection?
a rupture goes through all 3 layers of the aorta or cerebral artery
a dissection is a tear in the intima layer causing separation b/w the intima and media layer where blood flows into the separation
both life threatening
2/3 of people with an aortic dissection have ____
HTN
an aortic dissection most commonly involves what structures of the aorta?
ascending aorta
descending aorta
aortic arch
abdominal aorta
what are the s/s of an abdominal dissection?
sudden, severe sharp pain in the chest/upper back
SOB
faintness/dizziness
LBP
diastolic heart murmur, muffled heart sounds
rapid, weak pulse
heavy sweating
confusion
loss of vision
stroke symptoms/weakness/paralysis on one side of the body/trouble talking
what are ways to medically manage an aneurysm?
pharmacologics, monitoring, surgical repair
what drugs are used to manage aneurysms?
beta blockers
angiotensin 2 receptor blockers
statins
if in the early stages, ____ will be used
monitoring
how is monitoring used in aneurysm management?
imaging done every 6 months following diagnosis
what imaging techniques are used to manage aneurysms?
echocardiogram
CT scan
MRA
what are surgeries done to manage aneurysms?
repair of the aneurysm/dissection where it occurs
open heart surgery
abdominal aortic aneurysm repair
cerebral aneurysm clipping or endovascular coiling
peripheral vascular surgery
what is open heart surgery?
aortic arch or root replacement or repair
thoracic aneurysm repair (open or TEVAR)
is an AAA repair always open surgery?
no, it can be TEVAR
what cause the structural changes in PAD?
degenerative conditions
infection
inflammation
narrowing of the vascular lumen in PAD is affected by what 3 things?
atherosclerosis
thrombosis
inflammation
symptoms appear in PAD when the athroma is so large it interferes with what?
blood flow to distal tissues
why does PAD cause pain with exercise?
bc the demand for blood flow to the skeletal muscles of the LE increases with exercise but the arteries can’t provide adequate supply due to stenosis and obstructions
when do symptoms of PAD occur?
when the blood flow isn’t adequate to meet the demands of peripheral tissues
what are changes in body structure and function related to decreased blood flow to peripheral tissues?
denervation to muscle
loss of muscles fibers
limb ischemia
limb ischemia leads to increased risk for what?
limb loss
what impairments can result from decreased blood flow to peripheral tissues?
decreased muscle strength w/atrophy
decreased sensation
decreased muscle and aerobic endurance
what is claudication?
muscle pain that develops as a result of ischemia in limbs from decreased blood flow
what percent of pts with PAD have clinically significant CAD?
40%
as PAD progresses, pts can develop…
pain at rest
skin changes
tissue necrosis
what are the signs of PAD?
dry, shiny skin
hair loss
thick toenails
muscles atrophy
rubor on dependency
round wounds with regular borders
increased pallor in the foot with elevation
nectrotic tissue in toes and feet
decreased pulse below blockage
what are the symptoms of PAD?
intermittent claudication
impaired sensation
pain in lower leg w/activity or at rest
how is PAD diagnosed?
using the ankle brachial index, pulse volume recordings, arterial duplex US, rubor on dependency, or exercise studies
what is the ankle brachial index?
non invasive means of quantifying degree of arterial insufficiency
requires a Doppler and BP cuff
divide the SBP of the ankle by SBP of brachial artery
in the ABI is the ankle or brachial pressure normally higher?
ankle
what is a normal ABI?
greater than 0.9