Chronic Obstructive Pulmonary Diseases Flashcards
does obstructive disease produce obstruction of expiratory or inspiratory flow?
expiratory
airflow obstruction can be related to:
retained secretions
inflammation of muscosal lining or airway walls
bronchiole constriction
weakening of support structures of airway walls
air sac destruction
air sac overstimulation w/destruction of surfactant
with obstructive disease, there is a decrease in the size of what structures?
bronchiole lumens
with obstructive disease, there is an increase in the size of what structures?
alveolar sacs
what conditions lead to decreased size of the bronchiole lumens and increased size of the alveolar sacs and resistance to expiratory flow?
COPD and obstructive diseases
what leads to hyperplasia of the mucus secreting cells, reactive airways, destruction of terminal bronchioles, and actual alveolar sacs destruction
obstructive disease
what disease is associated with enlarged submucosal glands?
chronic bronchitis
what disease is associated with smooth muscle constriction?
asthma
what disease is associated with destroyed alveolar walls and fused into one large sac?
emphysema
what is the most common cause of COPD?
smoking
can genetics cause COPD?
yes
what is one pack year?
smoking 20 cigarettes a day for a year
is how many cigarettes you smoke or how old you were when you started smoking more important?
how old you were when you started smoking
what is the cycle involved in COPD starting with inhalation exposure?
inhalation exposure –> inflammatory response–> increase in protease activity and decrease in anti protease activity–> breakdown of elastin and CT–> hyperplasia of mucus-secreting cells
what are the physical impairments of COPD?
inflammation, decreased elastic lung recoil, decreased O2 perfusion, rib cage takes on barrel shape, diaphragm flattens, pelvic floor dysfxn
why is there a decrease in O2 perfusion in COPD?
bc there is a lack of gas exchange from decrease elastic recoil
why is there pelvic floor dysfxn in COPD?
bc they have more forceful exhalations that increase abdominal pressure and puts pressure on the pelvic floor
what are the accessory muscles of inspiration?
SCM, scalenes, upper trap, and pec group
t/f: decreased strength of both skeletal and respiratory musculature are “independently associated w/poorer exercise capacity and lower extremity functioning across the spectrum”
true
what is usually the cause of an inability to exercise in COPD?
LE weakness
what factors affect aerobic metabolism and poor muscle endurance?
a shift from type 1 to type 2
reduction in mitochondrial density per fiber bundle
reduction in capillary density
high pro-inflammatory mediators
what are the psychological impairments of obstructive disease?
SOB causes anxiety and depression which leads to sickness and further weakness
what disease leads to lung hyperinflation?
obstructive disease
what are common physical signs of obstructive lung disease?
elevation of the shoulder girdle
horizontal ribs
barrel-shaped thorax
low, flattened diaphragm
would radiographic mechanical changes in structures of obstructive lung disease be found early on?
no, only in ppl with severe disease
are the results of radiographs or spirometry more important in early obstructive lung disease?
spirometry
what is the gold standard for dx of bronchiectasis? (KNOW THIS)
CT
what are the symptoms of obstructive lung disease?
dyspnea on exertion, esp during functional activities
may have increased anxiety levels
secretion production and cough
is COPD associated with larger or smaller lung volumes and capacities?
larger
is vital capacity normal or increased/decreased in obstructive disease ?
normal to decreased
are residual volume and functional residual capacity normal or increased/decreased in obstructive disease?
increased
is total lungs capacity normal or increased/decreased in obstructive disease?
normal to increased
is the RV/TLC ratio normal or increased/decreased in obstructive disease?
increased
does FEV1/FVC ratio increase or decrease with disease progression of COPD?
decreases
what is the FEV1/FVC ratio in obstructive disease?
<70%
what is normal FEV1/FVC ratio?
75%
with obstructive disease, is there a difference with in PFTs pre and post bronchodilators?
there can be
what % of change in PTFs pre and post bronchodilators would indicate a meaningful change?
12%
t/f: the use of bronchodilators prior to exercise w/PT may improve pt’s exercise tolerance
true
COPD is the __ leading cause of death
4th
t/f: COPD is preventable and treatable
true
what is COPD?
chronic airflow limitation caused by mix of parenchymal alveolar disease (emphysema) and small airway disease (obstructive bronchiolitis)
COPD is a combo of what 2 obstructive diseases?
emphysema and obstructive bronchiolitis
what are the risk factors for COPD?
cigarette smoking, air pollution, inhalation of smoke or noxious particles
what is the most common risk factors for COPD?
cigarette smoking
what is emphysema?
condition of the lungs characterized by destruction of alveolar walls and enlargement of air spaces distal to the terminal bronchioles
what are the subtypes of emphysema?
centrilobular (centriacinar)
panlobular (panacinar)
distal acinar (paraseptal)
what is the most common cause of emphysema?
heavy smoking
what is the most common subtype of emphysema?
centrilobular
t/f: the lungs can repair itself with emphysema
true
what is effected by centrilobular emphysema?
the central part of the respiratory unit
what is effected by panlobular emphysema?
the distal component of the respiratory unit
what is affected by distal acinar emphysema?
closer to the septum
how does a patient with emphysema present?
older
thin
severe dyspnea
quiet chest
hyperinflation
flat diaphragm
how does a patient with chronic bronchitis present?
overweight
cyanotic
elevated hemoglobin
peripheral edema
rhonchi and wheezing