Exam 1 Flashcards
The six levels of organization of the body
chemical, cells, tissues, organs, organ systems, organism
Anabolism
To build
Catabolism
To break down
What three things does development include
Differentiation/specialization of cells, growth, and reproduction
Hyperplasia
Proliferation, increase in number of cells
Hypertrophy
Increase in cell size
What are the three basic nutrients required for life
Water, energy, and micronutrients (V&M)
Hormeorhesis
The orchestrated or coordinated control in metabolism of body tissues necessary to support a psychological state
What are the four requirements for life
Oxygen, nutrients, Narrow range of temp, Narrow range of atmospheric pressure
Sagittal plane
Divides left vs right sides; midsagittal, parasagittal, or longitudinal
Forntal plane
Divides anterior (front) vs posterior (rear); also called coronal
Transverse plan
Divides upper vs lower; also called cross section
What allows for specilization and is seen in every level of A&P
Compartmentalization
Pleural cavity surrounds
The lungs
Peritoneum surrounds
The organs in the abdominal cavity
What is the role of serous (serosa) membranes
Thin membranes that cover organs/walls; similar to saran wrap, acts to separate; helps avoid friction
Isotope
Contains an equal number of protons, but a different number of neutrons in the nuclei
What causes an isotope to be radioactive
They decay from a less stable form to a more stable form
How are radioactive isotopes detected
Decay causes emissions of alpha, beta, or gamma particles that are detectable
How are stable (non radioactive) isotopes detected
By mass spectrometry
What are the three types of chemical reactions
Synthesis, decomposition, exchange
What are the three key inorganic compounds
Water, salts, acids/bases
Acids
Donate H+ in solution, have a lower pH
Bases
Donate OH- or accept H+ in solution; have a higher pH
Buffer
Solution of a weak acid and its conjugate base, act to soften blow and equalize things
Two types of acidosis and how they occur
Metabolic occurs when reactions generate CO2 or acidic compounds or loss of base while respiratory is when low respiration fails to exhale CO2
Two types of alkalosis and how they occur
Respiratory is when hypervenilation blows off too much CO2 raising blood pH and metabolic often is due to diarrhea and loss of HCl
What are the 5 important monosaccharides
Hexoses (6C): glucose, fructose, galactose, pentoses (5C): ribose, and deoxyribose
What are the three important disaccharides and what bonds do they have
Sucrose: glucose and fructose bind together
Lactose: galactose and glucose bind together
Maltose: two glucose monosaccharides bind
What are the three important polysaccharides
Starch, glycogen, and cellulose
Hydroxyl
Polar; components of all four types of organic compounds; involved in dehydration synthesis and hydolysis reactions
Carboxyl
Found in FA, AA, and other acids
Methly
Found w/in AA
Phosphate
Found w/in phospholipids and nucleotides
Glycosaminoglycans (GAGs) examples
Hyaluronic acid, heparan sulfate, dermatan sulfate, chondroitin sulfate
Saturated FA
Linear, have a higher melting point than unsaturated; straight
Unsaturated FA
Kinked chain, more fluid; double bonds bend the chain so they dont stack as tightly, therefore have a lower melting point
What is the precursor for steroid hormones and prostaglandins
Cholesterol
What are the big four of the phospholipids
Phosphatidylserine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol
How does the delta system nomenclature for lipids work
Carbons are counted from the methyl (omega) end
What are the four different shapes of proteins
Primary, secondary, tertiary, quaternary
What type of reaction forms a peptide bond
A dehydration condensation reaction
What is a peptide bond
Bond between AA
What are enzymes classified as
Proteins
What are the function of proteins
Structural, hormonal, buffers, electrolyte transport, bind water, bind CHO, energy source (de-amination)
What three things do nucleotides need
A phsophate head, a sugar, a nitrogen containing base
What bond is present between bases
Hydrogen
Three components of a cell membrane
Phospholipid bilayer, cholesterol, embedded proteins
The cell membrane allows for compartmentalization of of what three fluids
Intracellular fluid (ICF), intercellular fluid (ECF), interstitial fluid (IF)
What model describes the structure of the plasma membrane as a mosaic of components that give the membrane a fluid character
Fluid mosaic model
What is in the fluid mosaic model
Phospholipids, cholesterol, proteins, and CHO
What are the three integral membrane proteins
Channel proteins, receptors, and glycoproteins
What are glycoproteins
Proteins covalently bonded to CHO
What are glycoproteins responsible for
Cell identity/recognition
What is the glycocalyx
A dense, gel like meshwork that surrounds the cell constituting a physical barrier for any object to enter the cell
What cell structure has an important role in immune function cell-cell recognition, communication, and intercellular adhesion
Glycocalyx
The cell membrane is _____ permeable
Selectivelt
What are the two types of passive transport
Diffusion/osmosis (permeable, concentration gradient) and facilitated transport/diffusion (not normally permeable, concentration gradient, specialized transport)
What are the two different types of transporters
Channel proteins and carrier proteins
How do channel proteins work
They are less selective and usually let more than one thing through
How do carrier proteins work
They are more selective only allowing a particular molecule or group of molecules to pass
Where in the body is there a higher affinity for GLUTs (glucose transporters)
In the brain needs it to compete w/ the rest of the body’s need for glucose
What is hydrostatic pressure
The force exerted on the capillary walls by the volume of fluid w/in the intravascular space, this forces fluid out of cavities and large particles can’t make it out
What is the flow of hydorstatic pressure
Higher to lower
Does the arterial or the venous side of a capillary have higher pressure due to capillary fluid exchange and hydrostatic pressure
Arterial side is high pressure venous side is low pressure
What is edema
A buildup of swelling because of a blockade or an increase in permeability
What is active transport
Movement of particles up a concentration gradient that requires energy
What is endocytosis and what type of transport is it
Engulfs and brings in as an intracellular vesicle and requires ATP this is active transport
What is pinocytosis
Type of endocytosis that involves “cell drinking” or internalizing of fluid + contents
What is phagocytosis
Type of endocytosis that involves cell eating or ingesting of large particles
What is exocytosis
A type of active transport that involves vesicles in a cell, membranes of vesicle and cell wall fuse contents are released into extracellular space
What is the endoplasmic reticulum
A series of membrane bound nuclear membrane w/ lots of SA for embedded proteins and reactions
What is the RER responsible for
Protein synthesis
How do proteins get to the golgi apparatus
From the RER proteins are exported through vesicles
What is the SER responsible for
Lipid synthesis
In steroid producing cells like in the testes and ovaries, what organelle is abundant
SER for lipid synthesis
What are the two sides of the golgi apparatus
Cis which recieves vesicles from the ER and trans which releases new vesicles
What is the puprose of the golgi apparatus
A stack of membranes to sort, modify, and send proteins to target site also performs post transciptional modifications
What is a lysosme
“Membrane bound bag of TNT”/large vesicle containing hydrolyic enzymes
What is autophagy
“Self eating”/The lysosomal digestion of the cells own components
What are phagolysosomes
Phagocytized material (bacteria) vesicle fuses w/ lysosome vesicles that get internalized, fused, and killed/ killing chamber
What is autolysis
Cell self destruction that is digested from the inside
What is apoptosis
Programmed cell death avoids inflammation since contained
What is the purpose of the mitochondria being highly folded
Higher SA for more cellular respiration and making ATP
What does mitochondria contain that other organelles do not
Its own DNA
What is the endosymbiosis theory
Proposes that mitochondria originated when a bacterial cell took up residence inside another cell
What is the evidence for the endosymbiosis theory in mitochondria
It has an outer membrane lipid bilayer and an inner membrane lipid bilayer
What are peroxisomes
Membrane bound vesicles that play a role in detoxification
What does catalase do in peroxisomes
Catalase catalyzes reactive oxygen species (ROS) which can cause damage to organelles and molecules
What is oxidative stress in basic terms
When reactive oxygen molecules build up and cause damage and is a theory for aging
What is the purpose of the cytoskeleton
Structural framework needed for shape, motility, transport, polarization, reproduction, and attachment
What are the three fibrous proteins of the cytoskeleton
Microtubules, microfilaments, and intermediate filaments
What gives polarity to a cell
Cytoskeleton
What three important components do microtubules make up
Cillia, flagella for the locomotion in sperm cells, and centrioles for cell division
What are the functions of microtubules
Cell motility, mitosis, intracellular transport, cell shape, and resist cell compression
What are the two microfilament components of muscle cells
Actin ratchet w/ myosin
What is the purpose of microfilaments
Cell contraction, movement, transport, and division
What are intermediate filaments composed of
Fibrous subunits of keratin wound into a rope
What is the purpose of intermediate filaments
Cell shape and structure, resist tension, anchor organelles w/in cells and anchor cells to each other and extracellular membrane
What is the organization of DNA w/in the nucleus
DNA wraps around a histone becoming a nucleosome, nucleosomes are wound together becoming a chromatin, chromatin gets wound together and becomes a chromosome
What are the two steps in protein synthesis
Transcription and translation
What speciality might focus on studying all of the structures of the ankle and foot
Regional anatomy
What is the smallest independently functioning unit of an organism
Cell
A collection of similar tissues that performs a specific function is an
Organ system
ATP is an important molecule because it does what
A process whereby new cells are formed to replace worn out cells
Humans have the most urgent need for a continuous supply of
oxygen
CJ is stuck in her car during a bitterly cold blizzard. Her body responds to the cold by
Breaking down stored energy
Stimulation of the heat loss center causes
Sweat glands to increase their output
What is the position of the body when it is in the normal anatomical position
The body standing upright w/ the feet at shoulder width and parallel, toes forward, upper limbs held out to each side, and palms of the hands facing out
Where is the lumbar region
Superior to the popliteal region
What are the four elements that make up more than 95% of the body’s mass
Oxygen, carbon, hydrogen, and nitrogen