Ewing Sarcoma Flashcards
What is a sarcoma?
A malignant tumour that arises from connective tissue origin.
Who is Dr. James Ewing?
An individual associated with the study of Ewing’s sarcoma, which is the most common bone tumour in pediatrics.
What percentage of childhood cancers does Ewing’s sarcoma account for?
1%.
What is the most common site for Ewing’s sarcoma?
The femur.
What are ‘Small Blue Round Cells’?
Cells that lack specific markers for lymphoma, neuroblastoma, and rhabdomyosarcoma, with a diffuse pattern being the most common.
What age range does Ewing’s sarcoma typically affect?
5 months to 60 years, peaking at 10-20 years of age.
True or False: Ewing’s sarcoma is commonly inherited.
False.
What is the known cause of Ewing’s sarcoma?
Relatively unknown; not inherited and no identifiable risks.
What type of chromosomal abnormality is commonly associated with Ewing’s sarcoma?
Fusion transcript involving chromosome rearrangement between genes on Chromosome 11 and 22.
In which bones does Ewing’s sarcoma most often occur?
Extremities, particularly in the long bones.
What are common symptoms of Ewing’s sarcoma?
Pain, swelling, redness, palpable mass, pathological fracture, pyrexia, weight loss.
What imaging techniques are important for determining the extent of Ewing’s sarcoma?
CT, MRI, PET/CT, Bone Scan.
What is a ‘Skip Metastasis’?
A secondary tumour separate from the primary tumour, occurring in the same bone or adjacent joint.
What is the significance of tumour grade in Ewing’s sarcoma?
It is a significant prognostic factor, with grades classified as G1 (low), G2 (high), G3 (Ewing’s).
