Evolution, genes, environment & behaviour (chapter 3) Flashcards
What do genes carry the blueprint for?
Making our whole body, including the brain
What are half of our genes estimated to target?
Brain structure and function (Kolb & Whishaw, 2003)
What is behavioural genetics?
A field of psychological science dedicated to investigating how genes and the environmental factors interact during the course of development so as to affect behaviour
What is evolutionary psychology?
A field of psychological science that investigates the evolutionary origins of various psychological traits
What do evolutionary psychologists argue?
That important aspects of human psychology and social behaviour, including aggression, altruism, nepotism, and mate choice , are influenced by evolved biological mechanisms
What is evolution (biological)?
Gradual change over time in organic life from one form into another
What does the theory of evolution suggest?
That life on Earth has been subject to a low, but inexorably powerful, process of change
What is natural selection?
Characteristics that increase the likelihood of survival and reproduction within a particular environment will be preserved in the population and therefore become more frequent over time
What is natural selection based on? (3)
It is an undirected/’blind’ process based on three factors:
1) biological variation
2) high reproduction rates and the fact that not all members of a population survive
3) competition over limited resources (Lewin, 2005)
What might some of these biological differences convey?
An advantage in terms of survival and reproduction. E.g. some members of a particular prey species may possess more acute hearing than others and hence be better able to detect and avoid predators
What can happen if adaptive traits are heritable?
They can be biologically passed on from parent to infant, and over time they will increase in frequency in the population
What does natural selection affect?
Not just physiological features (such as degree of furriness) but also behavioural traits
What can be seen, behaviourally, when the genomes of dogs and wolves are compared? (experimental evidence)
The largest areas of difference were related to brain function and nervous system development. Other findings concerning differences in interaction with humans.
These findings cannot be easily explained in terms of differences in learning or experience, since both species in the experiment were raised in a similar manner. Thus it would seem that certain behaviours, such as visually orienting to humans, are under the influence of inherited biological factors.
How do new traits emerge in a population if organisms faithfully inherit parental characteristics?
Genetic mutation
What are mutations?
Random events and accidents in gene reproduction during the division of cells
What do mutations do?
Help create variation within a population’s physical and behavioural characteristics. It is this genetic variation that makes evolution possible.
What is the blending theory?
Blending suggests that parental traits are blended together rather like mixing white and red paint to produce pink
What is a problem with blending?
It is incompatible with natural selection (Jenkin, 1867)
Blending traits eliminates variability. Without variability, natural selection cannot operate because it has nothing to select among. Thus, one would end up with the mean or average pattern and any behavioural differences would be due to learning from the environment.
Who solved the puzzle of inheritance?
an Austrian monk, Gregor Mendel in the 1860s
How were the laws of inheritance worked out?
Through conducting elegant experiments on pea plants. Mendel used a pea plant which produces either all green, all yellow or a mixture of green and yellow peas
How did Mendel carry the experiments out?
Used a baseline parent generation (P). He prevented them from self-fertilizing and manually cross-fertilized them. The resultant peas in the following generation (F1) were all yellow: the green characteristic had completely disappeared. He then planted the F1 generation and allowed the resultant plants to self-fertilize. The F2 peas showed that the green trait had re-emerged in an overall ratio of 3 yellow:1 green. He then left these to self fertilise and found that of this generation (F3), the green peas grew into plants which only produced green peas , one third of the yellow plants produced all yellow peas and the remaining plants produced the same 3:1 ratio again.
What did Mendel propose following his findings?
That the yellow was the dominant trait, and the green was recessive. Furthermore, as the yellow peas from the cross-fertilized plants grew into plants that produced both green and yellow peas, they must still have been carrying the green trait, but unexpressed. Mendel proposed that heredity factors (genes) must come in double doses - each of which is called an allele. The particular combination of dominant and recessive alleles determines the outwardly expressed characteristic of an organism or its phenotype.
What is a dominant characteristic?
The particular characteristic that it controls will be displayed (AA)
What is a recessive characteristic?
The characteristic will not show up unless the partner gene inherited from the other parent is also recessive (aa)
What is an allele?
Alternative forms of a gene that produce different characteristics
How to gametes differ from other cells?
They only carry one allele.
How do the complementary pairs of alleles come together from sex cells?
They come together in different combinations during fertilization. Organisms that receive the same alleles, that is, two dominant or two recessive, for a trait are called homozygous and organisms with different forms of alleles, one dominant and once recessive, are called heterozygous
What does homozygous mean?
Organisms that possess the same type of allele for a trait, either two dominant or two recessive
What does heterozygous mean?
Organisms that possess different allele for a trait, one dominant and one recessive
What is the genotype?
The specific and complete genetic make-up of the individual
What is the phenotype
The individual’s outward observable characteristics
When is genotype present from?
Conception
What is phenotype affected by?
By both other genes and the environment. The same phenotype can have different genotypes.
How can the same genotype have the same phenotypes?
Identical twins have the same genes, but if one eats more than the other they will differ in the phenotypic expression of body weight.
What are Phenylketonuria and Huntington’s disease (relation to genes)?
They are directly relevant psychological conditions which manifest themselves primarily in terms of psychological malfunctioning. They are both based upon the inheritance of specific combinations of the alleles from single genes
What is Phenylketonuria (PKU)?
PKU is associated with developmental delay and severe learning difficulties (Williams et al., 2008). It occurs at a rate of approximately 1 in 10,000 births. Often parents of children with PKU do not exhibit the condition. It runs in families and it tends to occur at a higher incidence in small, inbred communities (sometimes referred to as the Kissing Cousins Disease)
What is PKU based on/how is it inherited?
It is based on the inheritance of a double dose of recessive alleles (pp).
If a parent is homozygous for the dominant allele (PP), they cannot pass on the disorder.
If one parent was a carrier (Pp) and the other parent is not (PP), none of their children will develop the disorder, but there is a 50% chance that they will be a carrier.
If both parents are carriers, they themselves will not have the disorder, but their offspring will have a 25% chance of inheriting two recessive alleles and being born with PKU
What is Huntington’s disease?
A degenerative disorder in which the sufferer experiences personality changes along with decreasing mental, memory and movement functioning over time. It affects 1 in 20,000 people. The average age of onset is 40 years old and generally one parent has the condition and his/her children have a 50% chance of passing it onto their children (Plomin et al., 2013)
What is Huntington’s based on/how is it inherited?
HD is based upon the inheritance of a dominant allele; so that the inheritance of the condition is somewhat similar to that found with yellow peas. Unaffected individuals have two recessive alleles, while affected individuals have usually inherited one of the dominant alleles from their affected parent.
Statistically, it would be very unlikely that two heterozygous (Hh) for HD would meet and have children, however if this did occur then their children would have a 75% chance of developing the condition, with a 50% chance of the child being heterozygous (Hh) for the condition, and a 25% chance of them inheriting a double dose of the dominant allele (HH)
Why does HD remain in the population?
Because of its late onset. Since the disorder does not being to manifest itself until the affected individual is around 40 years of age, and by that time they will often have had children. Those children will have a 50:50 chance of inheriting the dominant allele from their affected parent and so in turn eventually manifest the symptoms of HD
What are genes?
Genes are functional segments of a long molecule called deoxyribonucleic acid or DNA
What does each gene carry?
The chemical code for manufacturing specific proteins, as well as the codes for when and where in the body they will be made
What can proteins do?
Proteins can take many forms and functions, and they underlie every bodily structure and chemical process. For that reason, DNA has been described as the blueprint for the body.
Since the mapping of the entire human genome, how many genes are humans thought to have?
It is now thought that humans have around 20,000 genes. The average gene has about 3,000 chemical base pairs, but sizes vary greatly; the largest gene has 2.4 million bases. It is estimated that about half of all genes target brain structure and functions.
What is a chromosome?
A single or double stranded structure comprised of proteins and deoxyribonucleic acid (DNA)
Where are chromosomes found?
They are only found within a cell’s nucleus. They come in pairs.
What form do chromosomes take?
They take the form of a single strong or rod (called a chromatid) until they copy themselves prior to cell division, which is when they assume their iconic X-like shape.
What are chromosomes comprised of?
Proteins and DNA. Histone proteins are tiny structures around which the string of DNA is wound rather like thread on a cotton reel. If unravelled, the DNA molecule, although invisible to the naked eye, would be approximately 6 feet or 2 meters long.
What is a somatic cell?
A somatic cell is any cell forming the body of an organism. They do not contain reproductive cells.
What do all non-sex or somatic cells contain?
The diploid number of chromosome, which constitutes the full complement with both members of each pair being present (except for red blood cells that have no nucleus)
What do sex cells or gametes contain?
The haploid number of chromosomes comprised of only one of each of the pairs from one or other of the parents, that is, 23 in humans.
What does diploid mean?
Diploid is a cell consisting of two sets of chromosomes
What does haploid mean?
Haploid is half the number of chromosomes found in a gamete
What is a gamete?
Sex cells (eggs and sperm)
What is a zygote?
A zygote is a fertilized egg containing 46 pairs of chromosomes
What happens when the human egg and sperm combine?
The fertilized egg or zygote contains all 46 chromosomes, with one of each pair coming from the father and its complementary pair from the mother. The fact that there are complementary pairs of chromosomes relates to alleles. Each gene is represented twice (i.e. as alleles) at the same locus (which is Latin for place; the plural is loci) on each of the chromosome pairs.
What are chromosomes made of?
Made of two substances: nucleic acids and proteins.
Proteins are much more varied than nucleic acids. They are molecules made of chains of approximately 100 amino acids.
What does the precise order or amino acids along the chain determine?
The type of protein. There are 20 kinds of amino acids, thus there are 20 to the 100 possible combinations (20 to the 100 is more than the total number of atoms in the universe. Since there are so many potential proteins, initially scientists thought that proteins must contain the heredity code. instead, the code for life is found in the nucleic acid, DNA
Why does DNA have a distinctive structure?
Discovered by Watson and Crick (largely based on the experimental work of Wilkins and Franklin in the early 1950s), it has a geometric shape of a double helix, which looks a bit like a twisted ladder. The rails of the ladder are made up of alternating sugar and phosphate molecules. The rungs are made up of pairs of four chemical or nitrogenous bases - adenine (A), thymine (T), guanine (G) and cytosine (C). It is as if the ladder rungs are made of two halves locked together: the chemical base guanine is always opposite cytosine, and adenine is always opposite thymine.
How does DNA allow for very accurate copying?
During replication, the two halves of the ladder split lengthways down the centre and each half can be used as a template to reconstruct the whole again. When the ladder is split, free-floating nucleotides in the cell are attracted to their complementary open bases on the DNA strand. It is rather like a self-assembling, four-piece, 3D jigsaw
What are nucleotides?
Nitrogenous base, phosphate and sugar groups
What is a codon?
A non-overlapping triplet sequence of nucleotides
What creates the specific commands to make functions in your body?
The sequence of the four letters of the DNA alphabet (A,T,G and C) creates the specific, commands for every feature and function of your body. The basic unit of the genetic code is made up of non-overlapping triplet sequences of nucleotides each of which is called a codon. With four different ‘letters’ of the DNA alphabet being read in non-overlapping triplet sequences, there are 64 possible combinations or permutations, 444.
What are the two type of statements that the triplet sequences can make?
One type specifies an amino acid and the other signals ‘stop’ in the sense that it stops the process of ‘translating’ a gene. With 20 types of amino acid and a stop sign, the total number of statements needed is 21. With 64 possible permutations, there is a great deal of overlap in the triplet code so that nearly every type of amino acid is specified by more than one codon.
What other kind of nucleic acid helps with DNA transcription?
Ribonucleic acid or RNA. RNA has a simpler structure than DNA. It is comprised of a single strand of nucleotides. In addition, instead of the sugar being deoxyribose as it is with DNA, it is ribose in RNA. RNA has the same nitrogenous bases as DNA except that instead of thymine it has uracil
Where does transcription begin?
In the nucleus of he cell
What happens in transcription?
A section of DNA unzips itself exposing the nitrogenous bases of a gene. The nucleotides of messenger RNA (mRNA) are attracted to their complimentary bases and they form into a continuous strand along the length of the gene.
This strand of mRNA then travels out of the nucleus into the cytoplasm of the cell. A large molecule called ribose then travels along the length of the mRNA activating its codons as it goes. When a codon is activated, transfer RNA (tRNA), which is floating loose in the cytoplasm, fixes itself to its complementary codon, rather like a three-pronged key fitting into a lock. Specific amino acids are attached to the surface of particular types of tRNA. The particular amino acids from each tRNA bond together and forma chain.
This chain will fold into a particular shape depending on the order of the different types of amino acids along its length. The shape that the amino acids form determines the specific type of protein they become. Transcription is a very complex process.
What is the most important thing to understand about genetic transcription?
That the end product is a protein
Why are statements like “a gene for eye colour” and “a gene for autism” technically incorrect?
Since genes primarily code for proteins, it is not technically correct to state that there is a gene for any time of phenotypic feature. Genes influence phenotypic expression in a more indirect manner. Nonetheless, since proteins are involved in every structure of the body (including the brain) DNA has a profound effect on our cognitive processing, personality and behaviour
What does it mean when a condition or trait is monogenic?
They are based upon the influence of one gene