Evidence references Flashcards
<p>Ralph Steinman</p>
<p>- Discovered DCs in 1973- Nobel Prize 2011- "potent accessory cells"</p>
<p>Maillard et al</p>
<p>2004- 3rd generation DC cancer therapy- Pittsburgh Cancer Institute- Current trials: cutaneous TC lymphoma, melanoma, CRC, prostate cancer- Using principle of functional polarization of DCs to develop a novel protocol to generate human DCs combining the 3 critical features for induction of Type 1 immunity: (a) fully mature status; (b) responsiveness to SLO chemokines; and (c) high interleukin-12 producing ability</p>
<p>Sir James Gowans</p>
<p>1950-1960s</p>
<ul> <li>discovered that lymphocytes mediate the immune response</li> <li>lymphocytes are long-lived cells that recirculate between blood and lymph</li> <li>showed these small, apparently non-dividing lymphocytes react with antigens to initiate immune responses during which they enlarge, divide, and differentiate into effectors</li> <li>recirculation provides a mechanism for selecting then directing lymphocytes of the correct specificity to lymphoid tissue in which antigen has localised</li></ul>
<p>Polly Matzinger</p>
<p><strong>2002</strong>(with her dog Galadriel Mirkwood)</p>
<ul> <li>danger hypothesis in TC activation</li> <li>a danger signal is required for co-stimulation expression on APCs, which is what is needed for TC activation instead of anergy</li> <li>danger signals act as an additional check on the recognition of self/non-self in tolerance or response</li> <li>Pradeau & Cooper (2012) Frontier Immunol 3; article 287</li></ul>
<p>Coley</p>
<p><strong>1891</strong></p>
<ul> <li>cultured bacteria for injection into cancer patients <ul> <li>some success</li> <li>Strep pyogenes + Serratia marcescens</li> </ul> </li> <li>based off earlier observations <ul> <li>1700s - association between infection and cancer regression</li> <li>1884 - Anton Chekoc noticed streptococcal infection caused prostate cancer remission</li> </ul> </li></ul>
<p>Villani et al</p>
<p><strong>2017</strong></p>
<ul> <li><u>reclassification of DCs based on single-cell RNA sequencing</u></li> <li>found DC subsets distinct from DC1 and DC2 (cDC1 and 2, respectively)</li> <li>reclassificed pDC as DC6</li> <li>identified different types of monocytes which may be related to or be precursors of certain DCs</li></ul>
