Cytokines

Question 1

<p>Type I interferons (5)</p>

Answer 1

<ol> <li>IFN-α</li> <li>IFN-β</li> <li>IFN-K (-ε, -κ, -τ, -δ and -ζ)</li> <li>IFN-ω</li> <li>IFN-ν</li></ol>

Question 2

<p>Type II interferons</p>

Answer 2

<p>IFN-γ</p>

Question 3

<p>Type III interferons</p>

Answer 3

<p>IFN-λ</p>

Question 4

<p>IL-4 (DC)</p>

Answer 4

<p>Induces <em>in vitro</em> peripheral blood monocytes (CD14+) development to immature DCs,with GM-CSF</p>

Question 5

<p>GM-CSF/CSF2</p>

Answer 5

<p><strong>Granulocyte-macrophage colony-stimulating factor</strong></p>

<ul> <li>WBC growth factor</li> <li>stimulates stem cells to produce <ul> <li>granulocytes (neutrophils, eosinophils, and basophils)</li> <li>monocytes</li> </ul> </li> <li>monocytes exit the circulation and migrate into tissue <ul> <li>mature into macrophages and dendritic cells.</li> </ul> </li></ul>

Question 6

<p>GM-CSF/CSF2 (DC)</p>

Answer 6

<p>Induces <em>in vitro</em> peripheral blood monocytes (CD14+) development to immature DCs,with IL-4</p>

<p></p>

Question 7

<p>IFN-γ (Th source + fx)</p>

Answer 7

<p>Source: Th1</p>

<ul> <li>promotes cell-mediated immunity against <ul> <li>intracellular pathogens</li> <li>viruses</li> <li>mycobacterium</li> </ul> </li> <li>activates <ul> <li>CD8+Tc</li> <li>macrophages</li> </ul> </li></ul>

Question 8

<p>IL-4 (Th source + fx)</p>

Answer 8

<p>Source: Th2</p>

<ul> <li>promotes humoral immunity against: <ul> <li>extracellular pathogens</li> <li>helminths</li> </ul> </li> <li>promote BCs</li></ul>

Question 9

<p>IL-17 (Th source + fx)</p>

Answer 9

<p>Source: Th17</p>

<ul> <li>provides protection of mucosal/surface tissues against: <ul> <li>bacteria</li> <li>fungi</li> </ul> </li> <li>promotes recruitment of neutrophils</li></ul>

Question 10

<p>IL-10 + TGFβ(DC)</p>

<p></p>

Answer 10

<p>Induces <strong>stable tolerogenic</strong>mature DCs</p>

Question 11

<p>Induction of stable tolerogenic DCs (3)</p>

Answer 11

<ul> <li>Cytokines: IL-10 + TGFβ</li> <li>Drugs: dexamethasone, vitamin D3, BAY 11-7082</li> <li>Genetic engineering: expression of IL-4, IL-10, FasL</li></ul>

Question 12

<p>Maturation cocktail for DC cancer immunotherapy (3rd gen)</p>

Answer 12

<ul> <li>TNF</li> <li>IL-1</li> <li>IFN-γ</li> <li>IFN-α</li> <li>Poly I:C</li></ul>

Question 13

<p>LN homing cytikines (2)</p>

<p>What binds them?</p>

Answer 13

<p><strong>CCL19, CCL21</strong></p>

<ul> <li>CCR7</li></ul>