Evidence Based Medicine Flashcards
Step One
Transforming an idea into a focused question
Step Two
Finding the best evidence with which to answer that question
Step Three
Critically appraising that evidence for validity, impact and applicability
Step Four
Integrating that appraisal with our clinical expertise and our pt’s unique circumstances and values
Step Five
Evaluating our effectiveness in this process
Progression of translational sciences
Animal based or physiology studies Case reports or case series Critical literature reviews Observational studies Randomized control trials Population based studies
Systemic review
Sum up the best available research on a specific questions
Synthesizing the results of randomized control trails (strong) and observational trials (weak)
What MUST systemic review have?
Clear inclusion/exclusion criteria
Explicit search strategy
Systemic analysis of studies
Meta-analysis where possible
Observational Studies
Effective in studying rare diseases Quick and inexpensive Generate hypotheses Some may be conclusive Suffer from biases bc of non-comparability of exposure groups
Randomized studies
Eliminate bias by controlling factors Causes and effect Remove bias in allocation to treatment Costly and time-consuming Restricted on the scope of questions addressed
Define Case Reports
Detailed report about a pt’s: diagnosis, treatment, course of illness and followup
Define Case Series
Detailed report about a group of pt’s: diagnosis, treatment, course of illness, followup
Preferred
Answer
Restate the question
Summarize results
Conclude