Evans - Sample, reference Ranges And Reliability Flashcards
1
Q
Clinical reasons for taking samples
A
Diagnosis
Management
Screening: cholesterol, neonatal; phenylketonuria
2
Q
Non invasive Types of clinical sample
A
Urine Saliva Hair Faeces Breath
3
Q
Invasive types of clinical samples
A
Blood (serum/plasma) Serous fluids (peritoneal, pericardial, pleural) CSF Amniotic fluid Sputum Calculi (stones)
4
Q
What is the workflow in a typical clinical biochem lab?
A
Patient > Testing > Response
5
Q
At What stage of the workflow in a clinical biochem lab do most of the issues occur?
A
Pre-analytical stage
6
Q
What are biological endogenous factors that contribute to sample variability in pre-analytical phase?
A
Age Pregnacy BMI Sex Menstrual status Ethnic origin Menopausal status Stress
7
Q
What are technical exogenous factors contributing to sample variability in pre-analytical phase?
A
Fasting, Exercise, Posture Patient prep Blood drawing Misidentification Insufficient volume Haemolysis Contamination Venous stasis Blood collection devices Automation Centrifugation Automation Medication Timing of sample collection
