Evaluation of drug therapies - treating Sz

Question 1

What did Thornley et al 2003 review?

Answer 1

studies comparing the effects of chlorpromazine to control conditions where patients received a placebo

Question 2

What data did Thorney et al 2003 collect?

Answer 2

data from 13 trials with 1,121 participants - demonstrated that CH was associated with better overall functioning and reduced symptoms

Question 3

What did Meltzer 2012 conclude?

Answer 3

that clozapine is more effective than typical antipsychotics and other atypical psychotics including the 30-50% treatment resistant cases

Question 4

Problems with evidence of effectiveness?

Answer 4

Healy suggested some successful trials have had their data published numerous times exaggerating the evidence of positive effects

Question 5

Serious side effects?

Answer 5

Typical AP associated with a range of effects from dizziness, sleepiness, weight gain and itchy skin

Question 5

Overall evaluation for drugs?

Answer 5

Cheaper
Less disruptive
Accessible
Side effects
Addictive