Etomidate

Question 1

Etomidate Mechanism of Action

Answer 1

Assumed to enhance the effects of GABA via GABA A receptor with B3 subunits

Question 2

Etomidate Protein Binding

Answer 2

75%

Question 3

Etomidate Metabolism

Answer 3

Hydrolyzed to inactive metabolites via ester hydrolysis (does not matter how much you give, everyone goes to sleep/wakes up in same amount of time)

Question 4

Etomidate Elimination Half Life

Answer 4

75 minutes

Question 5

Etomidate Excretion

Answer 5

85% renal, 15% biliary

Question 6

Etomidate CV Effects

Answer 6

Decreases: SBP, SVR. Increases: HR

Question 7

Etomidate Pulmonary Effects

Answer 7

Minimal respiratory depression, increased with opioids

Question 8

Etomidate CNS Effects

Answer 8

Decrease: CBF, ICP, CMRO2

Question 9

Etomidate Supplied as

Answer 9

2 mg/ml vials

Question 10

Etomidate Induction dose

Answer 10

0.2-0.4 mg/kg

Question 11

Etomidate Things to be aware of

Answer 11

Burns on injection, causes myoclonus, increases PONV, no analgesia ***adrenal suppression

Question 12

Etomidate Adrenal Suppression***

Answer 12

Inhibits 11 beta-hydroxylase- decreases cortisol and aldosterone - and to a lesser extent 17 alpha-hydroxylase - higher up in chain inhibits conversion to 11 beta-hydroxylase