Droperidol

Question 1

Droperidol Mechanism of Action

Answer 1

Acts centrally at sites where dopamine, NE, & serotonin act- alters CNS signal transmission, exerts antiemetic effect at red astrocytes in CRTZ great for motion sickness, moderate alpha adrenergic blocking ability. May occupy GABA receptors on postsynaptic membrane causing buildup of dopamine in intersynaptic cleft (cannot be utliized = contraindicated in Parkinsons patients), causes neuroleptic anesthesia

Question 2

Droperidol CV Effects

Answer 2

Decreased: SVR, MAP Neutral: CO, Contractility Changes in QT (prolonged) may cause R on T phenomenon, torsades de Pointes & delayed repolarization

Question 3

Droperidol Respiratory Effects

Answer 3

Minimal

Question 4

Droperidol CNS Effects

Answer 4

Decreased CBF in dogs, no human data. Worsening of extrapyramidal side effects, contraindicated in Parkinsons

Question 5

Droperidol Uses with dose

Answer 5

Antiemetic 0.625-1.25 mg IM or IV in adults, must have EKG 1 hour after giving.. give early!

Question 6

Droperidol Onset

Answer 6

5-8 minutes

Question 7

Droperidol Volume of distribution

Answer 7

2 L/kg

Question 8

Droperidol Duration of action

Answer 8

3-6 hours

Question 9

Droperidol Elimination half life

Answer 9

1.7-2.2 hours

Question 10

Droperidol Metabolism

Answer 10

Hepatic transformation into 2 metabolites

Question 11

Droperidol Excretion

Answer 11

Liver & Renal

Question 12

Droperidol Chemical structure (kind of)

Answer 12

butryphenone (heloperidol derivative)