Etiology and Pathogenesis of Periodontal Disease Flashcards

1
Q

What are some common infections in the oral cavity?

A
Caries
Periapical Lesions
Fungal 
Viral
Abcesses
Periodontal
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2
Q

two basic forms of periodontal diseases are

A

Gingivitis

Periodontitis

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3
Q

How much of attached gingiva do you loose annually w/ periodontitis?

A

0.1 eh… inches….

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4
Q

Nonspecific accumulation of plaque causes?

A

Gingivitis

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5
Q

What are the three things required for a disease?

A
  1. ) Microbial plaque
  2. ) Genetics
  3. ) Acquired/Environmental factors
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6
Q

What was the 70’s theory to periodontal disease?

A

Direct plaque was related to increased severity of disease

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7
Q

Etiology of Periodontal disease to cause microbial plaque (5)

A
Bacteria
Fungus
Protozoa
Virus
Mycoplasm
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8
Q

What two things are required for periodontal disease?

A

Dental Plaque

Endotoxins

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9
Q

What is calculus?

A

Dead bacteria that have been mineralized

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10
Q

Benefits of a biofilm?

A

Commuication
Quorum sensing
Resistant to antibiotics and immune response

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11
Q

Bacteria found in the red complex.

A

Porphyromonas gingivalis
Bacteroids (Tannerella) forsythus
Treponema denticola

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12
Q

What complex are sreptococcus spp. found?

A

Yellow complex

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13
Q

Which complex is A.a. found?

A

Green complex

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14
Q

Bacteria attach directly to the?

A

Pellicle

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15
Q

The pellicle is composed of?

A

Salivary proteins

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16
Q

What are the 2 regulatory components in G - Quorum sensing

A

Transcriptional activator protein (R Protein)

AHL molecule

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17
Q

What does the fluid gradient provide in a biofilm?

A

Flow of nutrients and bacterial communication

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18
Q

Where is the most common location for sub-gingival plaque?

A

Posterior distal mid-buccal

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19
Q

Is there a relation between poor oral hygiene and the risk of developing periodontitis?

A

Eh, not really

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20
Q

What must always occur before periodontitis?

A

Gingivitis

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21
Q

name 3 that help prevent against phagocytosis

A

Fimbrea
Capsule
Endotoxin

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22
Q

What is the main thing that prevents infection?

A

Intact epithelium

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23
Q

When bacteria attach to a surface what are they avoiding?

A

Gingival crevicular fluid (GCF)

24
Q

How may bacteria enter the host?

A

Ulcerations

Direct penetration

25
Q

How man American suffer from gingivitis?

A

> 90%

26
Q

about how many adults suffer from periodontitis?

A

about half

27
Q

What is a formula for periodontal disease? (3)

A

Pathogenic flora
Lack of good flora
Susceptible host

28
Q

What are some healthy bacteria? (5)

A
Actinomyces spp.
Strep mitis
Strep sanguis
Capnocytophaga spp.
V. parvula
29
Q

How quickly do bacteria attach to the pellicle after a cleaning?

A

within hours

30
Q

What bacteria are generally associated w/ Supragingival plaque

A

Gram +

Aerobic

31
Q

What are the 2 plaques of Supragingival plaque?

A

Coronal

Marginal

32
Q

What bacteria are generally associated w/ Subgingival plaque

A

anaerobic

G -

33
Q

With Subgingival plaque you have

A

Attached

Unattached

34
Q

What layer is the most pathogenic?

A

Attached plaque

35
Q

Calculus attachment is

A

mechanical

direct

36
Q

layers of a pocket

A
  1. Calculus
  2. Attached plaque
  3. Unattached plaque
  4. junctional epithelium
  5. partially lysed ct fibers
37
Q

what is considered to be the “critical zone”

A

Partially lysed ct fibers

38
Q

unattached subgingival plaque mostly consists of….

A

Motile, gram

39
Q

unattached subgingival plaque is in direct contact w/ ?

A

Junctional and sulcular epithelium

40
Q

Young Supra-gingival Plaque

A

G+

aerobic

41
Q

Aged Supra-gingival Plaque

A

G-

anaerobic

42
Q

What bacteria are Strongly associated with periodontal disease?

A

A.a.
P. gingivalis
T. forsythia

43
Q

What bacteria cause abscesses of the periodontium? (5)

A
F. nucleatum (Fuse)
Prevotella intermedia (Provollon)
Peptostreptococcus micros (Pepsi)
Bacteriodes
Porphyromonas gingivalis
44
Q

Characteristics of A.a.

A
Non-motile
G -
Faculatative anaerobe
*Sccharolytic*
Coccobacillus
Starshapped colonies
*invades epithelial cells*
45
Q

Where is A.a. Prevalent?

A

LAP

46
Q

What toxin does A.a. produce?

A

Leukotoxin

47
Q

LPS as a direct relationship with….

A

bone resorption

48
Q

Characteristics of Prophyromonas gingivalis

A
G-
Anaerobic
non-motile
asaccharolytic
*Black pigmination*
*invades epithelial cells*
49
Q

fun facts of P. gingivalis

A

Grow in elevated pH

Thick capsule

50
Q

Characteristics of Tanerella forsythia (Bacteroides)

A
G -
anaerobic
pleomorphic
*co cultivation with F. nucleatum*
*invades epithelial cells*
51
Q

Characteristics of Prevotella intermedia

A

G-
anaerobic
Elevated in ANUG
Black pigmented

52
Q

Where do you find Fusobacterium nucleatum?

A

Sub-gingival samples

53
Q

Characteristics of Campylobacter rectus

A

G-
anaerobic
motile vibrio
Produces leukotoxin

54
Q

Characteristics of Peptostreptococcus micros

A

G+
anaerobic
asaccharolytic

55
Q

Spirochetes

A

G-
Smell bad
NUG