2. Pathogenesis of Periodontal Disease Lecture 1 MOD.

Question 1

What are Cardinal Signs of Inflammation?

Answer 1

rubor
tumor
calor
dolor
functiolaesa (no function)

Question 2

What causes acute inflammation?

Answer 2

Innate immunity

• serum complement
• neutrophil

Question 3

What causes Chronic inflammation?

Answer 3

Acquired immunity

• Macrophage
• Lymphocytes

Question 4

Describe clinical things of Initial Lesion?

Answer 4

Can’t see anything it looks healthy

Question 5

Four stages of Infection?

Answer 5

Initial,
Early
Established
Chronic (Adv)

Question 6

In Gingivitis what is the primary inflammatory cell that is present?

Answer 6

T lymphocytes

Question 7

When do you have plasma cells constituting over 50%?

Answer 7

Periodontitis

Question 8

WHen do you have plasma cell constituting to 10-30%?

Answer 8

Established gingivitis

Question 9

Histamine

Answer 9

Increase of blood permeability

Question 10

Chemotactic factors

Answer 10

PMN and Eosinophil

Question 11

TNF alpha

Answer 11

induce fever (granulocytes)

Question 12

Leukotrienes

Answer 12

bronchi constriction

Chemotaxis for leukocytes

Question 13

Prostaglandins

Answer 13

Permeability

regulates immune response

Question 14

When do Acute Phase Proteins (APC) decrease?

Answer 14

in response to inflammation

Question 15

When do plasma proteins increase?

Answer 15

w/ microbial infection

Question 16

What increases your case of a MI by 2-5 folds?

Answer 16

C-reactive protein

Question 17

PMN half-lifes are

Answer 17

short

Question 18

What attracts/causes E-selectin?

Answer 18

TNF alpha

Question 19

Azurophilic granules (primary granules)

Answer 19

Myeloperoxidase, BPI, Defensins, elastase and cathepsin G

Question 20

Specific granules (secondary granules)

Answer 20

anything you didnt memorzie

Question 21

Tertiary granules

Answer 21

Cathepsin, gelatinase

Question 22

List oxygen dependent PMN mechanisms… (3)

Answer 22

NADPH
Myeloperoxidase
superoxide disumatse
(LOOK FOR OXIDE)

Question 23

how many metalloproteinases are there?

Answer 23

17

Question 24

What are involved in periodontal tissue degradation?

Answer 24

Primary proteinases (MMP)

Question 25

Why are neutrophil proteases not thought to be a cause of tissue damage? (3)

Answer 25

1. antiproteases
2. latent inactive form
3. anti-oxidants

Question 26

what can HOCl do?

Answer 26

inactivate the 3 major anti-proteases

Question 27

the two types of healthy gingiva are?

Answer 27

Pristine

Clinical

Question 28

in periodontitist what happens with the JE?

Answer 28

it turns into an ulcerated PE