Ethnopharmacology 2 Flashcards
Use of POLAR or NON POLAR SOLVENTS to RECOVER desired components
Extraction
Capable of getting the compound
Extraction
Simple extraction includes
Stirring
Percolation
Complex extraction includes
Column
Pressurized
DIFFERENTIATES the bioactives from the non bioactives
Isolation
Isolation involves
Separation method (Chromatography)
Determine the ATOMS and FUNCTIONAL GROUPS as well as unveil STEREOCHEMISTRY
Identification
Identification includes
Structure elucidation
Carbon skeleton
Detailed picture with electron-density maps
To identify the COMPOUND and FUNCTIONAL GROUPS to readily manipulate or optimize its effects
Structure elucidation
Example to show the carbon skeleton
NMR
Example of detailed picture with electron-density maps
X-ray crystallography
Goal of identification
Identify specific compounds and replicate it
Use of STABILITY TECHNIQUES to avoid alterations in molecules
Standardization
It should be REPEATED to make sure it is correct
Standardization
Standardization is for
Storage conditions
- how factors in the environment can affect your extract
It is optimized medical benefits
Standardization
To make the bioactives MORE USEFUL as medicines
Synthesis
Synthesis is to purposely
Eliminate sourcing from plants
Synthesis is the ULTIMATE GOAL of
Ethnopharmacologic studies
A REFULFILLMENT
How would you SHARE it
Patent
It is done to PROVE and SECURE its NOVELTY
Patent application
Patent application is to
Recoup the costs of development
Sales and commercialization
Synthetic compounds are more ______________ than natural products
Patentable
A vast and ever growing network that involves the COLLABORATION of multi-disciplinary scientists in order to produce MEDICAL BREAKTHROUGHS
Ethnopharmacology
Not completed overnight and it’s process maybe TEDIOUS, VERY LONG and TIME and RESOURCE CONSUMING
Medicinal breakthroughs
It would take an average of ______________ to develop a drug product from is herbal source
8-25 years
