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Metabolic Pathways > ETC - online questions > Flashcards

ETC - online questions Flashcards

1
Q
A
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1
Q

1 NADH = How many ATP

A

2.5 ATP

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2
Q

1 FADH2 = How many ATP

A

1.5 ATP

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3
Q

How many H+ ions does it take to make 1 ATP

A

4 H+

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4
Q

1 NADH pumps how many H+ across

A

10

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5
Q

1 FADH2 pumps how many H + across

A

6

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6
Q

TCA occurs where

A

Matrix of mitochondria

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7
Q

OP Occurs where

A

Inner membrane of mitochondria

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8
Q

At the last step of OP each NADH or FADH2 produces what?

A

One water molecule

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9
Q

1 Glucose molecule = how many ATP

A

32 ATP (experimental yield)

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10
Q

Explain how NADH goes through the electron transport chain

A

Complex I > UQ > Complex 3 > Cytochrome C > Complex 4

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11
Q

Name each complex (4 of them) in the electron transport chain and how many hydrogen’s are pumped across

A

Complex I - 4 H+

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14
Q

Which complex is water created by

A

Complex IV

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15
Q

What kind of gradient is created by the electron transport chain

A

A chemical and electrical gradient

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16
Q

ATP Synthase is made up of what

A

F0 and F1

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17
Q

F0 is

A

The porin part or the part that lets the H+ ions go through it

18
Q

F1 is

A

The active site for the ADP > ATP reaction

19
Q

What are the 3 active sites in ATP Synthase in order

A

L > T > O

20
Q

Which is more negative ADP or ATP and why is this important?

A

ATP is more negative ; allows it to get out of the mitochondria due to the electrical gradients

21
Q

How do NADH from glycolysis get into the mitochondria?

A

2 Different Shuttle Mechanisms

22
Q

The Glycerophosphate Shuttle does what

A

NADH > FADH2

23
Q

What enzyme is used?

A

Glycerophosphate Dehydrogenase

24
Q

Malate Asparate Shuttle does what?

A

NADH > NADH

25
Q

Explain what happens

A

Oxaloacetate > Aspartate > goes and gets electrons off NADH > goes back into mitochandria > Oxaloacetate

26
Q

Retenone is an insecticide that does what

A

Inhibits complex I of the ETC

27
Q

Demerol or Meperidine does what

A

Inhibits complex I

28
Q

Amytal does what

A

Inhibits complex I

29
Q

Antimycin does what

A

Inhibits complex III

30
Q

Myxothiazol

A

Inhibits complex III

31
Q

Cyanide and Carbon Monoxide

A

Inhibit complex IV

32
Q

Oligomycin is a

A

Macrolide

33
Q

What does a macrolide (class drug) do?

A

Binds to the F0 or porin part of ATP Synthase and blocks proton flow

34
Q

Arsenic does what

A

Inhibits pyruvate dehydrogenase therefore we cannot enter the TCA cycle

Metabolic Pathways (9 decks)

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