ET : M - Cardiac Muscle Flashcards
How is contraction initiated?
Myogenic (involuntary - initiates contractions with nervous input)
What is the conductivity of cardiac muscles?
Electrically connected
How are the contractile filaments organised?
Into sarcomeres
What is the shape of the SR?
Rudimentary
Are cardiac muscles striated?
Yes (‘banded’ appearance)
What are cardiac muscles?
Forms the bulk of heart mass and its contraction pumps blood
What can’t the force of contraction be modulated by?
Recruitment - contraction is all or none
How is the heart structured?
A hollow multiple chamber organ, with 2 artrias and 2 ventricles, its volume changes during contraction to pump blood
What is the length and diameter of ventricular cells?
100 μm x 30 μm
What are ventricular cells shape?
Branched
What do the desmosomes do in ventricular cells?
Prevent cells from separating during contraction
What is the function and structure of gap junctions in ventricular cells?
Allows action potentials to be carried from one cell to the next, join cells together to form ‘sheets’ that divide and wrap around the ventricles
In ventricular cells, what do intercalated discs allow?
For the co-ordinated contraction of all myocytes
How are T-tubules structured in ventricular cells and what is the function of them?
Well-developed t-tubular system (at the Z discs), carries excitation into the interior of the cell
Why does the heart have numerous mitochondeia and large amounts of myoglobin?
Needs oxygen for oxidative mechanism as the tissue is primarily oxidative (doesn’t want build up of acid (H+))
How many nucleus does ventricular cells have and how does growth occur?
Each cell has generally 1 but can have up to 3, growth occurs mainly through hypertrophy with relatively little cell division (after birth)
How are action potentials initiated?
In a group of specialised cells in the right atria called the sino-atrial node
Where does the action potential spread?
Spreads throughout the atria and then via specialized conducting cells called Purkinje fibres to the ventricles
How long is an action potential?
> 100ms
Why is a cardiac action potential quite long lasting?
Due to the presence of additional ionic currents that hold the cell membrane potential depolarised throughout most of the twitch (heart beat)
During a ventricular myocyte action potential, what causes fast depolarisation?
Na+ influx through fast voltage-gated Na+ channels. A +ve feedback cycle rapidly opens many Na+ channels, reversing the membrane potential. Channel inactivation ends this phase
During a ventricular myocyte action potential, what causes the plateau phase?
The Ca2+ influx through slow voltage-gated Ca2+ channels (due to the presence of a large sustained inward Ca2+ current). This keeps the cell depolarized as few K+ channels are open
During the plateau phase of the ventricular myocyte action potential, what does the Ca2+ influx trigger and what is it balanced by?
It triggers the release of Ca2+ from the SR by a mechanism called calcium-induced calcium release (CICR). It’s balanced by a large Ca2+ extrusion capacity via a Na+/Ca2+ exchange mechanism
During the plateau phase of the ventricular myocyte action potential, what does the Na+/Ca2+ exchange mechanism produce and lead to?
It produces a depolarising current when it extrudes Ca2+, due to the fact that it brings 3 Na+ ions into the cell for each Ca2+ ion it extrudes. This also leads to a prolongation of the action potential
During a ventricular myocyte action potential, what causes repolarisation?
The Ca2+ channels inactivation and K+ (outward) channels opening. This allows K+ efflux, which brings the membrane potential back to its resting voltage
What is highly unlikely to occur during a ventricular myocyte action potential?
Summation/tetani of cardiac muscle (long action potential allows twitch to be almost completed before another action potential occurs so while the heart is relaxing, it can pump blood)