B & I - Coagulation

Question 1

what is coagulation?

Answer 1

blood clotting

Question 2

what are two pathways of coagulation activation

Answer 2

intrinsic and extrinsic

Question 3

what is the intrinsic pathway caused by

Answer 3

contact with surfaces

Question 4

what is the extrinsic pathway caused by

Answer 4

tissue damage

Question 5

what is the key enzyme common to both pathways

Answer 5

factor X (10)

Question 6

________ is essential at a number of steps

Answer 6

calcium

Question 7

what happens if calcium is removed

Answer 7

blood does not clot

Question 8

what does thrombin do

Answer 8

cleaves fibrinogen to fibrin which cross-links

Question 9

parasites and microbes that rely on blood flow produce what?

Answer 9

powerful anti-coagulants that typically target the thrombin step

Question 10

what is plasminogen converted to

Answer 10

active plasmin

Question 11

what does the conversion from plasminogen to active plasmin do

Answer 11

dissolves the clot

Question 12

what are plasminogen activators (such as TPA and streptokinase) used for?

Answer 12

treatment of thrombosis etc

Question 13

what does tissue damage or surface contact result in the binding and activation of?

Answer 13

platelets that bind to the vessel cell wall