Estrogens

Question 1

Estrogen preparations (6 drugs)

Answer 1

Conjugated equnie estrogens
Ethynyl estradiol
Mestranol
Micronized estradiol
Estradiol cypionate
Estradiol valerate

Question 2

Estrogens - cautions and contraindications

Answer 2

Contraindications: pregnancy, uterine fibroids
Caution: hepatic disease, endometriosis, thromboembolic disease, hypercalcemia

Question 3

Estrogens- adverse effects

Answer 3

Breast tenderness
Edema
Change in libido
Hypertension
Thromboembolic disorders
Gall bladder disease

Question 4

Mestranol & ethinyl estradiol - indications

Answer 4

Oral estrogen-progestin contraceptives
Acne vulgaris
Dysmenorrhea

Question 5

Estrogen used in heavy or prolonged menstrual bleeding

Answer 5

Estradiol valerate

Question 6

Micronized and transdermal estradiol can be used for

Answer 6

Hormone replacement therapy in postmenopausal women

Question 7

The contraceptive Natazia contains which estrogen?

Answer 7

Estradiol valerate

Question 8

Administration of estradiol cypionate and valerate

Answer 8

IM (slow release)

Question 9

Estrogens - MoA

Answer 9

Hypertensive effect: increases angiotensinogen synthesis
Thromboembolic effect: increased synthesis of clotting factors
Gallbladder disease: increased cholesterol excretion in bile
Decreases LDL, increases HDL
Epiphyseal closure
Prevents osteoporosis (inhibits bone resorption)
Bone and muscle growth
Endometrial growth
Female secondary characteristics
Sensitive myometrium to oxytocin
Protein synthesis in brain (mood)

Question 10

Estrogens - Clinical use

Answer 10

Primary hypogonadism

Cases caused by surgical oophorectomy and menopause