Antiandrogens

Question 1

Antiandrogens (3 groups)

Answer 1

GnRH analogues
Androgen receptor antagonists
5α-reductase inhibitors

Question 2

GnRH analogues (1 drug)

Answer 2

Leuprolide

Question 3

Leuprolide - indications

Answer 3

Inoperable prostate cancer

Question 4

Androgen receptor antagonists (5 drugs)

Answer 4

Flutamide
Bicalutamide
Enzalutamide
Nilutamide
Cyproterone

Question 5

Difference between cyproterone and other androgen receptor antagonists

Answer 5

Cyproterone is a steroidal androgen receptor antagonist, while the others (flutamide, bicalutamide, nilutamide) er nonsteroidal

Question 6

The nonsteroidal androgen antagonists - indications

Answer 6

Inoperable prostate cancer

Question 7

Flutamide, bicalutamide, nilutamide - adverse effects

Answer 7

Impotence
Gynecomastia
Hepatitis

Question 8

5α-reductase inhibitors (2 drugs)

Answer 8

Finasteride

Dutasteride

Question 9

5α-reductase inhibitors - MOA

Answer 9

Blocks 5α-reductase, decreases DHT synthesis. Reduces prostate volume

Question 10

5α-reductase inhibitors - indications

Answer 10

Symptomatic Benign Prostate Hyperplasia

Improve urinary flow and decrease risk of urinary retention

Question 11

Finasteride - indications

Answer 11

Male pattern baldness

Question 12

5α-reductase inhibitors - adverse effects

Answer 12

Aggressive cancer
Decreased libido
Erectile dysfunction
Gynecomastia