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LC Unit 1 > Estrogen & Progestin Drugs > Flashcards

Estrogen & Progestin Drugs Flashcards

1
Q

17-beta-estradiol (E2)

A

oral, transdermal, vaginal estrogen

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2
Q

Esters of 17-beta-estradiol (EE)

A

longer half life/more soluble estrogen

oral/IM

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3
Q

Estrone Sulfate

A

Oral synthetic estrogen

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4
Q

Premarin

A

conjugated equine estrogen

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5
Q

Ethinyl estradiol

A

oral birth control pill estrogen

Ethyl at postition 17 decreases hepatic degradation

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6
Q

Estrogen Side Effects

A

Oral increases hepatic production TBG, CBG, SHBG, TGs, HDL, cholesterol, & clotting factors

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7
Q

Tamoifen

A

SERM
Breast cancer
Endometrial cancer risk

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8
Q

Raloxifen

A

SERM

Osteoporosis

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9
Q

Toremiphene

A

SERM
Breast cancer
Endometrial cancer risk

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10
Q

Clomiphene

A

SERM

Infertility

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11
Q

Fulvestrant

A

Anti-estrogen
Full antagonist
Monthly IM
Breast Cancer

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12
Q

Aromatase Inhibitor

A

Anti-estrogen
Prevents androgen -> estrogen
Breast cancer (postmenopausal)
SE: joint probs, osteoporosis, hypercholesterolemia

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13
Q

Progesterone

A

oral, oil, vaginal, IUD

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14
Q

Provera/Depo-provera

A

Progesterone Esters
Longer
Oral vs IM

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15
Q

19-norestosterone derivatives

A

Primary component in OCs

Oral, subdermal, ethinyl estradiol, vaginal ring, transdermal

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16
Q

Progestin SE

A

Weight gain, depression, acne, thromboembolic, weak androgenic, breast discomfort, break through bleeding

17
Q

Mefipristone

A

Anti-progestin at uterus to terminate pregnancy
Given w/PGEs
Can also be postcoital contraceptive
SE: bleeding, N/V, diarrhea

18
Q

Estrogen Receptor A

A

Endometrium, breast cancer cells, & ovarian stroma

19
Q

ERb

A

Granulosa cells & nonclassic tissues (lung, kidney, bone, etc)

20
Q

Estrogen-like compounds

A

Phytoestrogens:
Isofalvones - soybeans, chickpeas, lentils
Coumestans - split peas, lima & pinto beans
Lignans - flaxseed, lentils, grains, F/V

Bisphenol A: synthetic in plastics

LC Unit 1 (10 decks)

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