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Basic Training Study Guide > Estrace > Flashcards

Estrace Flashcards

1
Q

The ___ is composed of a group of organs and structures that function to support pregnancy and reproduction. 5 Key components are?

A

Female Reproductive System

  1. Ovaries
  2. Fallopian Tubes
  3. Uterus
  4. Hypothalamus
  5. Pituitary Gland
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2
Q

___ has a main function for the development and release of the egg. Also they produce the hormone that controls the menstrual cycle.

A

Ovaries

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3
Q

____ has a main function to house the fertilized egg as it develops into the fetus/baby.

A

Uterus

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4
Q

___ has a main purpose of allowing the egg to travel down its tubes from the ovary to the uterus. This is where fertilzation mostly occurs.

A

Fallopian Tubes

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5
Q

___ has a main function of regulating the production of hormones from the pituitary gland.

A

Hypothalamus

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6
Q

___ has a main function of being the main endocrine gland responsible for the production of hormones that control the reproductive system.

A

Pituitary Glant

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7
Q

___ is the inner layer of the uterine wall.

A

Endometrium

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8
Q

Many hormones are involved in the menstural cycle, but 4 have ultimate control, what are they?

A
  1. Estrogen
  2. Progesterone
  3. Luteinizing Hormone
  4. Follicle Stimulating Hormone
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9
Q

___ is a sex hormone that is secreted by the ovaries which stimulates target organs of the reproductive system and stimulates the development of secondary sex characteristics.

A

Estrogen

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10
Q

____ is a steroid hormone that is secreted by the corpus luteum in the ovary that prepares and maintains the uterus for pregnancy.

A

Progesterone

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11
Q

___ is the hormone produced by the pituitary gland that stimulates ovulation

A

Luteinizing Hormone

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12
Q

___ is a hormone secreted by the pituitary gland that stimulates the maturation of ovarian follicles.

A

Follicle Stimulating Hormone

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13
Q

___ is defined as the permanent cessation of menstruation - that is the final menstrual period in a woman’s life.

A

Menopause

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14
Q

The median age of menopause in the US is ?

A

51.4

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15
Q

In post-menopausal women, instead of estrogen being secreted from the ovaries, ____ from a woman’s adrenal glands are converted into small amounts of estrogens by fatty tissues.

A

Androgens

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16
Q

This prolonged period of decreased ovarian function, which includes menopause, is known as the ___ or the transitional years.

A

Climacteric

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17
Q

The term ____ refers to the time span between the few years immediately prior to menopause and the first year after menopaus. This is usually what women refer to as “going through”

A

Peri-Menopause

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18
Q

For most women, the _____ (“going through”) begins before the age of 51 and last roughly ___ years.

A

Perimenopause

5yrs

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19
Q

The key physiological changes that develop from perimenopause are an eventual decrease in circulating levels of ___, the estrogen produced in the ovaries.

A

Estradiol

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20
Q

From Menopause, it is not uncommon that ___ occurs. This is when the number of follcles in the ovaries decline and the walls of the uterus and vagina become thinner and smoother.

A

Vaginal Atrophy

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21
Q

4 systems that are affected by menopause are?

A
  1. Vasomotor
  2. Vulvovaginal
  3. Neuropsychotic
  4. Skeletal
22
Q

What are two vasomotor symptoms of menopause?

A
  1. Hot Flushes

2. Night sweats

23
Q

What are 5 Vulvovaginal symptoms of menopause?

A
  1. Vaginal Atrophy
  2. UTI
  3. Dysuria (painful urination)
  4. Dyspareunia (painful sex)
  5. Urinary Incontinence
24
Q

____ is a menopausal symptom that is painful urination

A

Dysuria

25
Q

___ is a menopausal symptom that is painful or difficult sexual intercourse

A

Dyspareunia

26
Q

Loss of estrogen strongly effects the vaginal ____ (the cells lining the Vagina) which become pale, thin, and prone to trauma and ulceration.

A

Epithelium

27
Q

___ is the surgical removal of the uterus

A

Hysterectomy

28
Q

__ is the surgical removal of the two ovaries

A

Bilateral Oophorectomy

29
Q

___ is a metabolite of estradiol commonly found in urine, having considerably less biologic activity that estradiol but similar properties and uses.

A

Estrone

30
Q

Many of the signs and symptoms of menopause can be managed by the use of ____?

A

Estrogen Therapy

31
Q

Why is Estrace much better than over the count moisturizers and lubricants?

A

OTC do help with dryness, they do not address physiologic abnormalities like elasticity, flexibility and thinning of the vaginal walls

32
Q

Estrace Cream’s indicated in the treatment of ___ and ___. It is the only FDA approved and ____ estradiol cream.

A

Vulvar and Vaginal Atrophy

Bioidentical

33
Q

Estrace cream is available in a dosage of ____ estradiol cream which equates to ___mg.

A

.01% estradiol cream

.1mg

34
Q

Estrace is supplied in a ____g tube with a plastic applicated calibrated to deliver 1,2,3, or 4grams

A

42.5g

35
Q

The usual recommended dosage ranges of Estrace is ___ to ___ daily for 2wks and then gradually reduced to ____ the initial dose for a similiar period. A maintenance dose of ___g administered 1 to 3x per week may be used after restoration of the vaginal mucosa has been achieved.

A

2 to 4g for first 2 weeks
half the inital dose for the next 2wks
1g maintenance

36
Q

With Estrace, it is recommended that patients reevaluate periodically with their physician every ___ to ___ months to see in TX continuation is necessary.

A

3 to 6months

37
Q

___ means originating or produced outside of an organism, tissue, or cell

A

Exogenous

38
Q

Estrogen circulates in the blood largely bound to ___ and ___.

A

SHBG and Albumin

39
Q

___ is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. It inhibits the function of these hormones by not allowing them to freely enter the cells.

A

SHBG - Sex Hormone-Binding Globulin

40
Q

___ is the main protein of plasma which serves as a transport protein for many compounds, including hormones, when their specific binding globulins are saturates.

A

Albumin

41
Q

Estrace Cream should not be used in woman with any of these 8 conditions:

A
  1. Pregnant or suspected pregnancy
  2. Has undiagnosed/unusual vaginal bleeding
  3. Breast cancer (known, suspected, or hx)
  4. Neoplasia (known or suspected)
  5. DVT (Deep Vein Thrombosis) Active or HX - including PE
  6. Arterial Thromboembolic Disease active or recent HX (i.e. stroke)
  7. Liver disease or dysfunction
  8. Hypersensitivity to its ingredients
42
Q

___ is a long-term national health study that focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporosis in post menopausal women.

A

WHI - Woman’s Health Initiative

43
Q

___ is an estimate of relative risk. In the WHI. a HR of >1 indicated that it was happening to fast.

A

Hazard Ratio

44
Q

When feasible, estrogens should be discontinued for ___ weeks before surgery with risk of thomboembolism or during periods of prolonged immobilization such as hip sx)

A

4 to 6wks

45
Q

___ is the ratio of the incidence rate among individuals with a given risk factor to the incidence of those without it.

A

Relative Risk

46
Q

____ is the calculated probability of occurance of an event

A

Absolute Risk

47
Q

With ET (Estrogen Therapy), it has been shown that when coupled with a ___, the risk of endometrial hyperplasia decreases.

A

Progesterone

48
Q

List 7 key features of Estrace Cream

A
  1. It is the only bioidentical local estrogen cream approved by the FDA.
  2. Only local ET product containing Estradiol
  3. Nonliquefying base which at body temp is more viscous that Premarin
  4. Does not contain Benzyl Alcohol (irritant)
  5. Contains Stearyl Alcohol which acts as an emullient and thickener
  6. Dosing flexibility tailored to each patient
  7. Shown to improve vulvovaginal symptoms from estrogen deficiency within 15days of tx
49
Q

Among the estrogen therapies, _____ and ____ both use the 17B Estradiol derived from plants.

A

Estrace and Vagifem

50
Q

_____ is derived from urine of pregnant mares. It contains a complex mixture or conjugate of atleast 10 different estrogens.

A

Premarin

51
Q

One difference between Estrace and Primarin is that Estrace contains ____ which acts as a thickener.

A

Stearyl Alcohol

52
Q

What is Vagifem?

A

It’s an Estrogen Tablet that is the only other compound using the Estradiol derived from plants

Basic Training Study Guide (5 decks)

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