Comparative Analysis of Competitors

Question 1

List the 2 other big Estrace competitors

Answer 1

Premarin and Vagifem

Question 2

List 4 key concepts of Premarin.

Answer 2

1. Premarin is made of conjugated Estrogen from pregnant mares.
2. Premarin 1g=0.625mg CE
3. Premarin contains Benzyl Alcohol (irritant)
4. Premarin weakens condoms

Question 3

3 Key concepts of Vagifem

Answer 3

1. Vagifem is an Estradiol tablet inserted intra-vaginally.
2. Vagifem dose delivers 10mcg or 25mcg (1/4 dose that Estrace dose)
3. Vagifem dosing is 1tablet daily for 2wks and then 1 tablet twice weekly.

Question 4

List the 6 big Enablex competitors.

Answer 4

STDDMV

1. Sanctura
2. Toviaz
3. Detrol
4. Ditropan
5. Myrbetriq
6. Vesicare

Question 5

5 key concepts of Vesicare.
And company is ______?

1. Type of drug
2. Active Ingredient
3. dose(s)
4. Bioavailability
5. Half-Life

Answer 5

1. Muscarinic antagonist
2. Solifenacin Succinate - Active Ingredient
3. 5mg or 10mg doses
4. 90% Bioavailability
5. Long half-life (45-68hours)

Question 6

8 Key concepts of Myrbetriq.

1. Prodrug/Extended Release/ or Controlled
2. Active Ingredient
3. Type of Drug
4. Dose(s)
5. Important Adverse Reaction
6. ______ Inhibitor
7. Focuses on the ____.
8. Half Life

Answer 6

1. Extended Release
2. Mirabegron - active ingredient
3. Adrenergic agonist (targets adrenergic receptors)
4. 25mg or 50mg doses
5. Risk of increased blood pressure
6. CYP2D6 Inhibitor
7. Focuses on the storage phase of fill-void cycle and increases bladder capacity by relaxing detrusor muscle.
8. 50hour half-life

Question 7

5 Key concepts of Toviaz.

1. Prodrug/Extended Release/ or Controlled
2. Type of Drug
3. Dose(s)
4. Active Ingredient
5. Half-Life

Answer 7

1. Extended Release
2. Muscarinic Antagonist
3. 4mg or 8mg doses
4. Fesoterodine - active ingredient
5. 7hr half-life

Question 8

6 key concepts of Detrol LA.

1. Prodrug/Extended Release/ or Controlled
2. Active Ingredient
3. Type of drug
4. Dose(s)
5. Half-Life
6. Failed ____?

Answer 8

1. Extended Release
2. tolterodine tartrate - active ingredient
3. Muscarinic antagonist
4. 2mg or 4mg doses (oddly the recommended dosing is to start at 4mg and go down to 2mg if needed)
5. 8hr half-life
6. Failed to help pediatric OAB

Question 9

6 key concepts of Ditropan XL.

1. Prodrug/Extended Release/ or Controlled
2. Active Ingredient
3. Clinical Study adverse reaction
4. Dose(s)
5. Type of drug
6. Also indicated for ___?

Answer 9

1. Extended Release
2. Oxybutynin Chloride - active ingredient
3. Ingredient known to cause memory problems
4. 5mg, 10mg, or 15mg doses
5. muscarinic antagonist
6. Indicated of TX of pediatrics 6yrs and older for OAB sx from neurologic disorders.

Question 10

7 Key concepts of Sanctura.

1. Prodrug/Extended Release/ or Controlled
2. Type of drug
3. Dose(s)
4. Active ingredient
5. Administration
6. Alcohol warning
7. Half-Life

Answer 10

1. Extended Release
2. Muscarinic Antagonist
3. 60mg dose
4. Trospium Chloride - active ingredient
5. Take on empty stomach
6. Don’t consume alcohol 2hrs before dose
7. 35hr half-life

Question 11

7 Key ENABLEX selling points.

Answer 11

1. Selective antimuscarinic which acts on the detrusor muscle to prevent contractions.
2. Clinical studies - Safe and no effect on memory (important)
3. No significant effect on QT interval
4. Clinical studies- It reduced weekly number of UI episodes in as little as 2wks and sustained over 2yrs of TX.
5. In a 12wk open label study of previous treated patients of Oxybutynin or Tolterodine, when switched to Enables, UI weekly episodes decreased by 86% and daily by 62%.
6. 2yr extension study- very safe on 65 and older patients.
7. Most common adverse reactions are dry mouth and constipation