Essential Thrombocytosis

Question 1

What is ET?

Answer 1

Neoplastic proliferation of myeloid cells especially Platelets (RBCs and Granulocytes also increased.

Question 2

What is the mutation causing ET?

Answer 2

JAK2 mutation on chromosome 9 with substitution of valine for a Phe.

Question 3

What are some of the physical findings with Primary ET?

Answer 3

1. Splenomegaly in 40%

2. Aortic and Mitral valve thickening or vegetations may occur

Question 4

What would one expect to see on PB smear?

Answer 4

Platelets with abnormal morphology

Question 5

What are the primary risks involved with ET?

Answer 5

Clotting or Hemorrhaging

Question 6

What are the treatments used to bring the platelet count down?

Answer 6

1Hydroxyurea

2.Anagrelide

Question 7

What are some of the factors pre-disposing primary ET patients to Thrombosis?

Answer 7

1. Previous thrombosis
2. Advanced Age
3. Associated cadivascular risk factors i.e smoking