erythrocytosis Flashcards
which organ makes Epo
Kidney
what can cause high levels of Epo?
- hypoxia
- cancer
uterine fibroids
renal cysts
-
3 ways to treat PVera
- phlebotomy
- ASA/anticoags
- JAK2 inhib
neutrophilia can be caused by
demargination- exercise, pain, infection, steroids
- reactive - inflammation or infection
- bone marrow malignancy
How do you investigate lymphocytosis?
- monoclonal or polyclonal
eosinophilia can be due to
allergic reactions
parasitic infections
malignancy
DDX for monocytosis
- Chronic infection - TB, syphilis
- Chronic inflamm disease - IBD, RA
- Malignancy
symptoms of thrombocytopenia when
platelets < 30
Risk of spontaneous bleeding when platelets are how low?
< 10
platelets 10-30 what do you do?
treat if symptomatic
factors that may decrease production of platelets
- bone marrow disorder
- infection
- marrow toxin - alcohol
b12 deficiency or folate
increased destruction of platelets
- immune
- primary: ITP
secondary: infection, viral, SLE, drugs, Heparin-induced
what do you need to rule out to diagnose ITP
Hep B
Hep C
HIV
Immediate treatment of ITP is
- Steroids- prednisone
- IVIG
- splenectomy, immune suppression
- drugs that stimulate TPO
In MAHA you can have
low platelets
red cell fragments
TTP - thrombotic thrombocytopenia purpura
fibrin mesh
mutation in adamts13
when do you worry about TTP
red cell fragments and low platelets
ITP
TTP
HIT
no plt activation
plt activation bleed and clot
Just clot - plt activated
How do you treat TTP
plasmapheresis
Low platelets and High MPV think
immune thrombocytopenia
avoid NSAIDs and aspirin
patient from malaysia can have what type of thalessemia
alpha
CBC of thalessemia patient
- can have a normal hemoglobin with LOW MCV
when is beta Hb turned on?
6mo - 1 yr
Alpha thal disorders can present
IN UTERO - always need it
In thal RDW
wide range of red cell size high RDW
