CBC review Flashcards
when ferritin is low - absolutely diagnostic of
Iron def anemia
low retics
low ferritin
low serum iron
High serum transferrin ==>
iron def anemia
Rheum disorder chronic infection IBD malignancy renal disease think
Anemia of chronic disease
increased hepcidin low iron
Increase in hepcidin leads to
reduced RBC survival
reduced response to EPO
reduced iron utilization
in Iron def anemia vs Anem of chronic disease what is the soluble transferrin receptor like
Normal in ACD
Increased in IDA
Low EPO low Iron low TIBC low % transferrin sat INAPPROPRIATELY low EPO
ACD
Treating ACD
give EPO
hypersegemented neutrophils
megaloblastic film
B12 def
ROUND oval macrocytes
bulls eye red cells
think liver disease
lemon yellow
intrinsic factor antibodies
pernicious anemia
treatment of pernicious anemia
high dose B12
low retics what do you check
EPO levels
If iron stores are normal but there is red cell hemolysis where is it occuring?
Extravascular hemolysis
Investigations for hemolysis
- Increased retics
- Increased bili
- increased LDH
- ## Decreased haptoglobin
Red cell shape if hemolysis is extravascular
spherocytes
Red cell shape if hemolysis is intravascular
shistocytes
Function of haptoglobin
binds free iron
Factors causing red cell destruction
- drugs
- DIC
- antibodies
- infection
- MAHA TMA - reduced platelets and Hb
