ERGE Flashcards

1
Q

Morbilidad x compli …%

A
  • Ulceración esofágica 5%
  • Estenosis 4-20%
  • Esófago de Barrett 8-20%
  • Hemorragia ↓1%
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2
Q

Factores defensores anatómicos

A

Barrera antirreflujo:
- EEI
- Diafragma crural
- Ligamento freno-esofágico
- Ángulo de His

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3
Q

En Perú, el …% de ↑ 15 años síntomas de ERGE x semana

A

22

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4
Q

Sustancias que ↓ presión EEI

A

Secretina, CCK, glucagón, progesterona, NO, α-antagonistas, β-agonistas, serotonina, chocolate, etanol, café

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5
Q

Sustancias que ↑ presión EEI

A

Gastrina, motilina, α-agonistas, β-antagonistas, procinéticos, prote

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6
Q

Cuáles son las fallas en mecanismos defensores?

A
  1. Barrera antirreflujo
  2. Clearence esofágico
  3. Resistencia tisular
  4. Vaciamiento gástrico retardado
  5. H. pylori: protectos cepa CagA+
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7
Q

Tto

A

IBP dosis doble + ranitidna
IBP dosis doble
IBP
IBP 1/2
Anti H2 o cisaproda

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8
Q

Duración del tto

A

4-8 ss

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9
Q

Objetivo y dosis de tto de mantenimiento

A

Evitar reaparición síntomas y prevenir compli
Continua dosis 1/2 si síntomas después de 6 a 12 meses de suspender tto inicial

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10
Q

…% de px que tto de mantemiento

A

80

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11
Q

Cuándo cx?

A

Fundoplicatura si fracaso a tto, compli, evitar tto largo en jóvenes

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12
Q

Factores preepiteliales

A

Moco, HCO3 y capa acuosa

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13
Q

Factores epiteliales

A

Estruc:
-Membrana cel y complej. cel
Funcion:
- Transporte epitelial, tampones intra e intercel, proliferación capa basal

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14
Q

Según resistencia tisular, que factor tiene menos importancia defensiva?

A

Factor preepitelial

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15
Q

Cuál es el dx GS?

A

pHmetría 24 hrs: ↑6% es confirmatorio

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