Erectile Dysfunction

Question 1

Indication for Sildenafil Citrate?

Answer 1

Phosphodiesterase (PDE) vasodilator used for:
Erectile Dysfunction (Viagra®)
Pulmonary Arterial Hypertension (Revatio®)

Question 2

Mechanism of action for Sildenafil Citrate?

Answer 2

Vasodilator:
PDE-5 Inhibitor;
sustains the vasodilatory effects of nitric oxide-dependent synthesis of cGMP

Question 3

Side effects of Sildenafil Citrate?

Answer 3

ADVERSE EFFECTS
Common: headache, abnormal vision, dizziness, nasal congestion
SERIOUS ADVERSE EFFECTS
CV: MI, stroke, ventricular tachycardia, hypotension/shock
Hematology: anemia, leukopenia
OCULAR ADVERSE EFFECTS
Ocular: Retinal hemorrhage, NAION, vision loss, elevated IOP, cyanopsia (blue vision)

Question 4

What are the drug interactions of concern with Sildenafil Citrate?

Answer 4

Azole Antifungals, Erythromycins, Cyclosporine (Reduced metabolism)
Alpha-Blockers, Beta-Blockers (Additive)