Erectile dysfunction Flashcards
What drugs belong to the drug class phosphodiesterase-5 inhibitor (PDE5I)? (4)
Viagra, Cialis, Spedra, levitra
(sildenafil, tadalafil)
MOA of PDE5I?
It inhibits PDE5 which blocks cGMP –> GMP, so a PDE5I helps break down cGMP into GMP to cause dilation
3 things to test in lab when testing for erectile dysfunction?
testosterone, prolactin, luteinising hormone
2 special tests to take when testing for erectile dysfunction
ultrasound, NPTR (see if you’re getting erections overnight)
What CYP metabolises PDE5I?
CYP3A4
What affect do CYP3A4 inhibitors have on PDE5I?
CYP3A4 inhibitors will icnreae effects of PDE5I
What affects do CYP3A4 inducers have on PDE5I
CYP3A4 inducers may decrease effects of PDE5I
What are examples of CYP3A4 inhibitors that cause a drug-drug reaction wtih P (4)DE5I?
- ketoconazole
- erythromycin
- grapefruit
- ritonavir
What are examples of CYP3A4 inducers that have a drug-drug reaction wtih PDE (4)5I?
rifampicin
- phenobarbital
- phenytoin
- carbamazepine
What can happen if pDE5I and alpha blockers are used together?
Risk of sympotomatic hypotension
How long should a patient wait between taking their viagra and cialis medications if they need to wait at all? Why is there a wait period between the medss if there is a wait time?
4 hours
viagra is a PDE5I and cialis is an alpha blocker which has a drug-drug interaction
4 side effects of PDE5I?
- facial flushing
- headache (caused by vasodilation)
- blocked nose (vasodilation in nose)
- dyspepsia (heart burn)
Which PDE5I has the fastest onset of action? List all 4 in order
levitra, pedra, viagra, cialis
