Erectile dysfunction

Question 1

PDE5 inhibitors first line name a few and duration of action

Answer 1

sildenafil (1hr before sex
vardenafil (25-60 mins before)
tadalafil (30 mins before)
avanafil (30 mins before)

Question 2

what is most potent pde5

Answer 2

tadalafil longest do a up to 36hrs

Question 3

name a prostaglandin analogue used in ED

Answer 3

Alprostadil (not orally injection)
- seek advice if lasts longer erection (priapism)

Question 4

moa of PDE5

Answer 4

inc blood flow to penis. food reduces effect by delaying it

Question 5

s/e PDE5 (vasodilation)

Answer 5

HYPOtension, flushing, tachycardia ,headache, palpitation dyspepsia nasal congestion

Question 6

c/I of PDE5

Answer 6

reduced blood perfusion
MI, Unstable angina, recent stroke, hypo systoli < 90 or taking nitrates