Urinary freq, enuresis

Question 1

what drugs are used in urge incontinence

Answer 1

Antimuscarinincs

Question 2

examples antimuscarinics and moa

Answer 2

relax detrusor muscles of bladder

festefordine
toltoredine
darifenacin
solifenacin
oxybutinin (direct relaxant available as a patch

Question 3

2nd line in urge incontinece and what is it

Answer 3

mirabegron - beta 3 agonist

Question 4

cautions with mirabegron

Answer 4

inc QT prolongation
c/I in severe uncontrolled hypertension

Question 5

stress incontinence common in women esp after childbirth 1st line, 2nd line

Answer 5

bladder training exercise
2nd line Duloxetine (mod to severe; avoid abrupt withdrawal)

Question 6

Nocturnal enuresis children 1st line

Answer 6

Enuresis alarms stop after 2 weeks uninterrupted night sleep

Question 7

2nd line nocturnal enuresis

Answer 7

desmopressin in 5 + (adh analhoue)

Question 8

forms of desmopressin and s/e

Answer 8

s/e convulsion and hyponatrameia
available as sublingual or oral,dont give intranasally as inc s/e

Question 9

counselling for nocturnal enuresis with desmopresin

Answer 9

• restrict fluid intake esp in skimming avoid fluid overload
• stop in vomiing and diarrhoea avoidi concomitant drugs that increase vasopressin secretion

Question 10

drug that increase vasopressin secretion

Answer 10

tca’s