Equations Flashcards
1
Q
Vd
A
Vd = [drug]/Co
2
Q
Bioavailability (F)
A
Bioavailability = AUCoral/AUCiv * 100
3
Q
Elimination Rate
A
Elimination rate = CL*[drug]
4
Q
Kel
A
Kel = CL/VdKel = Kmetabolism + KexcretionKel = Khepatic + Krenal
5
Q
t1/2
A
t1/2 = 0.7 * Vd/CLt1/2 = 0.7/Kel
6
Q
Clearance
A
CL = rate of elimination from the body / plasma concentrationCL = (F*Dose)/AUC
7
Q
Concentration of drug in body
A
[drug in body] = Vd * Cp Cp = [drug in plasma]
8
Q
Concentration of drug at steady state (Css)
A
Css = input/outputCss = (FD/T)/(VdKel)Css = (FD/T)/CLCss = (1.44)(FD/T)*(t1/2)/Vd
9
Q
Loading Dose
A
LD = Css*Vd/F
10
Q
Maintenance Dose
A
Continuous IV admin: MD = CssCL/FIntermittent dosing: MD = ((CssCL)t)/F
