Equations 2 Flashcards
1
Q
Bioavailibility (F)
A
[Drug] oral/ [Drug] IV * 100
2
Q
VD
A
[Total Drug in the body] / [Drug in plasma]
3
Q
What is the relationship between CL, VD, KEL, t1/2?What is another definition of CL?
A
CL = VD x KELKEL = 0.693/ t1/2CL = F x Dose / AUCCL = rate of elimination of a drug/plasma dug conc.
4
Q
Loading dose
A
Loading dose = Css x VD / F
5
Q
Maintenance dose
A
Maintenance dose = Css x CL x t/ Fwhere t = time
6
Q
IV maintenance dose?
A
IV maintenance dose = Css x CL / F
7
Q
Css?
A
Css = 1.44 x [(F x D)/t] x t1/2 / VD
8
Q
Renal Clearence
A
Renal Clearnece = U x Cur / f x Cpwhere U is urine flow, Cur is urine concentration, Cp is plasma concentration and f is unbound drug in the plasma
