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FTM 1 Week 2 > Epithelium & Glands II > Flashcards

Epithelium & Glands II Flashcards

1
Q

Junctional complexes

A

occluding - tight - zonula occludes
anchoring - adhering(zonula adherens) & desmosomes(macula adherens)
Communicating - Gap

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2
Q

Zonula Occludens

A

Tight Junctions
localized sealing of mbrn of adjacent cells
anastomosing strands(zipping)
Claudins & Occluding
interaction with actin cytoskeleton via ZO-1, ZO-2, ZO-3

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3
Q

JAM

A

associated with ZO-1 & claudin

Present in endothelial cells; mediates interactions btw cells and monocyte adhesions

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4
Q

ZO-1

A

Important link in transduction of signals from all transmembrane proteins; interacts with actin filaments; has tumor-suppressor action

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5
Q

ZO-2

A

Required in the epidermal growth factor-receptor signaling mech.

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6
Q

ZO-3

A

interacts with ZO-1, occluding, and actin filaments of the cytoskeleton

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7
Q

Claudin

A

forms backbone of zonula occludes strands; forms and regulates aqueous channels used for paracellular diffusion

Susceptable to enterotoxins: mona zuna’s revenge (leaking… :-( )

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8
Q

Occludin

A

is present in most occluding junctions; maintains barrier btwn apical and lateral cell surface

Susceptable to enterotoxins: mona zuna’s revenge (leaking… :-( )

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9
Q

Zonula Adherens

A

Calcium dependent E-Cadherin proteins
Anchoring - lateral aspect, just below tight
15-20nm gap
Interact with actin

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10
Q

Macula Adherens

A

Demosomes
Lateral, localized, spot adhesion - 30 nm gap
Present: macula(spot)
beneath zonula adherens
Transmbrn pro: desmocollin & Desmoglein (Ca2+ dependent cadherins)
Intercellular plaque - Plakoglobins & Desmoplakins
Interact w/intermediate filaments - collogen

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11
Q

Gap Junctions

A

Communication
Location: epithelium, Smooth & cardiac Muscle, Nerve
Coordinate cellular activity
6 connexin to make a connexon

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12
Q

Lateral Interdigitations

A

Infoldings(plicae) of cytoplasm
Fluid & electrologist transport
Location: gallbladder, sm. intestine
Na+/K+ ATPase

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13
Q

Focal Adhesion

A 
Actin filament
Integrin to fibronectin
Anchoring Junction
Link btw cytoskeleton actin and ECM
cell migration
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14
Q

Hemidesosome

A

Intermediate filament
BP230, alpha6beta4 integrin, typeXVII collagen, laminin-332
cell to ECM junction
1/2 a desmosome

Dx: bullous pemphigoid; blister, antibodies directed against BP230 & Type XVII collagen

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15
Q

Basal Infoldings

A 
increase SA 
transport proteins and channels
Location: kidney tubule, striated ducts of exocrine glands.
Vertical mitochondria. 
LM - striated appearance
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16
Q

Basal Lamina

A

TEM - overlying epithelial cells and underlying connective tissue
“external lamina”
Composition: laminins, type IV collagen, Proteoglycans & glycoproteins.
2 layers: Lamina lucida (artifact). Lamina densa (electron dense)

17
Q

Podocyte

A

cells in the Bowman’s capsule in the kidneys that wrap around capillaries of the glomerulus

18
Q

Exocrine Glands

A

Merocrine - morn bound vesicles
Apocrine - bleb, lactating mammary
Holocrine - apoptosis, sebaceous

19
Q

Endocrine Gland

A

secrete product (hormones) into the connective tissue
Paracrine - nearby effect
Autocrine - same cell

20
Q

Simple Tubular

A

Lg. intestine, colon
straight tube
goblet cells

21
Q

simple coiled tubular

A

Skin: eccrine sweat gland

coiled tube, secretory portion deep in the dermis

22
Q

simple branched tubular

A

Stomach: pylorus mucus. Uterus: endometrial.
wide secretory portion
viscous mucous

23
Q

simple acinar

A

Urethra: paraurethral & periurethral
outputting of the transitional epithelium
single layer of secretory cells
“change purse”

24
Q

Branched acinar

A

stomach: mucus of cardia.
Skin: sebaceous
short, single-duct portion opens directly into the lumen

25
Q

Compound tubular

A

Duodenum: submucosal, Brunner.

coiled portions deep in submucosa

26
Q

Compound Acinar

A

Pancreas: exocrine.
alveolar-shaped
formed by pyramid-shaped serous-secreting cells

27
Q

Compound tubuloacinar

A

submandibular salivar gland

both mucous branded tube & serous branded acinar units. serous end-caps (demilunes)

28
Q

Serous glands

A 
watery - poor to no glycosylation
round/oval nuclei
zymogen granules - eosinophilic
basophilic perinuclear cytoplasm - rER
ex. pancreatic acinus, serous compound acinar gland
29
Q

Mucus Gland

A

viscous/slimy - extensive glycosylation
flattened/compressed nuclei
PAS positive
Mucinogen granules - poorly preserve, empty space with H&E

30
Q

Mixed Gland

A 
Mucous & serous
ex. submandibular gland
compound tubuloacinar gland
serous demilune - half moon cap
striated duct

FTM 1 Week 2 (6 decks)

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