Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Foundations 1 > Epithelium > Flashcards

Epithelium Flashcards

To memorize facts for the exam

1
Q

Pemphigus vulgaris defect = ?

A

IgG auto-abs to DG1 & DG3 (desmosome loss = flaccid blisters due to rupture inside epidermis w/ BM layer still in tact)Skin, vagina and oral, +Nikolsky sign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 3 locations of stratified squamous epithelium?

A
  1. Epidermis
  2. Oral cavity
  3. Esophagus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Initiating event or agent of a pathogenic series

A

Etiology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is pathogensis?

A

Biomolecular events that happens after cell injury, leading to structural changes in cell; several steps that leads from normal to abnormal.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Functions of epithelial cells

A

Protection, transportation, glandular secretion, sensation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What epithelium is found in respiratory spaces, bowman’s capsule, endothelium, mesothelium, and is selectively permeable barrier

A

simple squamous epithelium; needed for diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What epithelium protects, absorbs, secretes and is found in small ducts of exocrine glands, kidney tubules, thyroid follicles?

A

Simple cuboidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which epithelium abosrbs and secretes and is found in stomach, small intestine, colon, and gallbladder?

A

simple columnar epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which epithelium absorbs, secretes, transport and is found in bronchial tree, vas deferens, and epididymis?

A

Pseudostratified epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What protects and is found in epidermis of skin, oral cavity, and esophagus and is keratinized?

A

Stratified squamous epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What protects, conduits and is found in large exocrine glands and anorectal junction?

A

Stratified cuboidal epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What protects and conduits and is found in largest excorine (salivary duct) ducts, anorectal junction?

A

Stratified columnar epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is distensible (expands) protects and is found in lower urinary tract?

A

Transitional epithelium (urothelium), dome shaped, specialized stratified squamous epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Are glands multicellular or unicellular?

A

can be both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do exocrine glands secrete? Are they passive tubes?

A

They secrete into the apical surface, and ducts are not passive tubes as made up of epithelium that can change secretions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How do endocrine secrete hormones?

A

They directly release in the blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is merocine?

A

excocytosis of substance through apical surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is apocrine?

A

Budding transport, cargo still surrounded by PM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is holocrine?

A

Programmed cell death of secretary cells, gland products and debris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What do endocrines do?

A

Secrete through basal membrane, directly to blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is serous secretions?

A

Thin and watery (enzymes and proteins)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is mucous secretions?

A

Viscous and slimy (glycoproteins) , and cytoplasm is empty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Example of a unicellular exocrine gland?

A

Goblet cell, produce mucin (component of mucus) in GI and respiratory tracts

24
Q

Where is simple coiled tubular gland found in?

A

Eccrine sweat gland, deep in dermis

25
Q

Where is simple tubular gland found in?

A

Large intestine, intestinal gland of colon, formed by goblet cells

26
Q

Where is compound acinar found in?

A

Pancreas: excretory portions, pyrimid shaped, serous secreting cells

27
Q

What do microvilli do?

A

They are fingerlike projection of plasma membrane and cytoplasm and increase absorptive surface area of epithelial cells

28
Q

What kinds of microvilli are found in tubules? what is intestine?

A

Brush border: tubules, and striated border: intestine

29
Q

What is stereocilia?

A

Long, immotile microvilli, inner ear, vas deferens and epididymus; mechanoreceptors

30
Q

What does nodal cilia do?

A

Specialized motile cilia in embryo that is responisble for L/R asymmetry

31
Q

How does motile cilia work?

A

Dynein arms initate sliding movement

32
Q

What is primary ciliary dyskinesia called? mode of inheritance?

A

Kartagener syndrome and it is autosomal recessive

33
Q

defect in ciliary motility becasue of loss of dynein arms; poor mucous clearing: chronic bronchitis, sinusitis, penumonia, ottis media, hearing loss, smell loss, bronchiectus?

A

Primary ciliary dyskinesia or kartagener syndrome

34
Q

Primary ciliary dyskinesia patients are infertile beacuse and what due to impaired nodal cilia?

A

Immotile sperm and females eggs cannot be propelled in fallopean tube and situs invertus (L/R asymmtery cannot be patterned)

35
Q

What protein codes for Primary cilia (immotile cilia)?

A

Polysystin 1, 2

36
Q

Autosomal Dominant Polycystic kidney disease due to mut in polycystin proteins?

A

Defective primary celila, Mutiple cyst in kidney, very huge kidney as a result; aka ADPKD

37
Q

What does apical domain have?

A

Surface enzymes, ion channels, carrier proteins

38
Q

How do non-motile cilia respond to in kidney?

A

Fluid flow as a mechanoreceptor, letting calcium in–gene mut leads to cyst formation

39
Q

How many types of epithlial junctions

A

Zona Occludens (tight junctions, lateral), Zona Adherens (intermediate junctions, lateral), Macula adherens (Desmosomes, lateral), Gap junctions (connexons, lateral) and Focal adhesions (integrins, basal)

40
Q

What do epithlial cell junctions do?

A

Mediate cellular adhesions (cell-cell, cell-ECM) and mediate cellular communications

41
Q

E-cadherin, Epithlial cells, Ca dependent, interacts with catenins in cyto–link with actin filaments, altered in tumor metastasis, cell-cell interaction

A

cadherins

42
Q

heterodimer-a and beta chain, ca independent, cell-cell, cell-ecm, anchoring junctions, adhesion of white blood cells to endothelial cell surface

A

Integrins

43
Q

Barrier between apical and basal membrane?

A

lateral domain

44
Q

most apical junctions, prevents paracellular transport, made of occludin and claudin

A

Zona occludens-tight junction

45
Q

anchor cells to eachother and made of up actin, e-cadherin-cantenin complexes

A

Zonula adherens, intermediate junctions

46
Q

What does cadherins, desmoglein, desmocollin bind to?

A

Desmoplakin, plakoglobin (Macula adherens) (dense plaques) which keratin also binds to

47
Q

Rapid intercellular communications, made up of connexin, which form connexons?

A

Gap junctions

48
Q

Two regions of basement membrane?

A

Basal lamina (penetration of this–> metastasis) and reticular lamina (type 3 collagen)

49
Q

Stain Basement membrane with?

A

PAS+, Silver-reactive (proteoglycans are present)

50
Q

Composed of integrins and link cytoplasmic actin to ECM

A

Focal adhesions

51
Q

Anchor basal membrane to basal lamina, made up of BP320, erbin, plectin?

A

Hemidesmosomes

52
Q

What does BP230 attach to

A

Laminin 5 and Type IV collagen

53
Q

What anibody agaonst Bullous pemphigoid (fluid filled and intact epidermis)?

A

IgG to BP230 (hemidesmosomes ) or type VII collagen– tense blisters that do not rupture easily and no Nikolsky sign

54
Q

Inherited defect in Collagen VII(no more anchorage to basement memebrane) ?

A

Dystophic epidermolysis bullosa (pts called butterfly children)

55
Q

How can pemphigues vulgaris (icantholysis) be detected?

A

net like IF

56
Q

How cam bullous pemhigoid be detected?

A

Linear IF on basement membrane, linear IF

Foundations 1 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions