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Mnemonics > Epilepsy Drugs > Flashcards

Epilepsy Drugs Flashcards

1
Q

Sodium blockers include

A
  1. LAMOTRIGINE
    2.PHENYTOIN
    3.CARBAMAZEPINE
    4.TOPIRAMATE
    3.SODIUM VALPORATE
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2
Q

One antiepileptic drug with broad spectrum of activity

A

Sodium Valporate

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3
Q

Calcium channel blockers

A
  1. Gabapentin
  2. Ethosuximide
    3.Topiramate
  3. Sodium valporate
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4
Q

Antiepileptic that targets t-type calcium channel

A

Ethosuximide

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5
Q

Inhibitors of Glutaminergic activity

A

1.Topiramate
2. Perampenel
3.Felbamate
4. Rufinamide

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6
Q

Agents that enhance GABA activity

A

1.BARBITURATE
2.BENZODIAZEPINE
3.sodium Valporate
4.Topiramate
5.Vigabatran
6.Tiagaban

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7
Q

MOA of Benzodiazepines

A

Increases the frequency of opening of the GABA mediated Cl channels

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8
Q

MOA OF BARBITURATES

A

Increase the duration of opening of the GABA MEDITAED Cl channels

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9
Q

Antiepileptic that ehances K+ inhibition

A

Retigabine

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10
Q

MOA of Levetiracetam

A

Binds to the synaptic glycoprotein ligand 2A to enhance GABA activity
Additionally blocks Ca channels in brain 🧠

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11
Q

Agent of choice in Generalized seizure

A
  1. Sodium Valporate (preferred as it blocks majority of channels)
    But due to SE ;
  2. LAMOTRIGINE can be used
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12
Q

Alts used in Generalized onset

A

Carbamazepine
Topiramate
Phenobarb
Phenytoin

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13
Q

Drug of choice with focal onset

A

First line: Carbamazepine or Levetiracetam

Alt : LAMOTRIGINE, Phenytoin or Topiramate, Sodium Valporate,Phenobarb, Garbapentin, Lacosamide

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14
Q

Preferred drug for Absence seizures

A

Ethosuximide

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15
Q

Why is Ethosuximide the preferred drug for Absence seizure?

A

They inhibit t-type Ca channels

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16
Q

Apart from Ethosuximde in Absence seizures what can be used?

A

Valporate or LAMOTRIGINE

17
Q

Preferred in Atonic seizure

A

TOPIRAMATE AND SODIUM VALPORATE

18
Q

PREFERRED AGENTS IN MYOCLONIC

A

Clonazepam, Sodium Valporate, LAMOTRIGINE

19
Q

What is the term for seizures during menstruation?

A

CATAMENIAL SEIZURES

20
Q

What is the presentation of Catamenial seizures

A

Seizures 3days before, during or right after menstruation

21
Q

What causes Catamenial Seizures?

A

An imbalance between Estrogen and Progesterone. ie high Estrogen or low Progesterone. ESTROGEN IS A PROCONVULSANT while PROGESTERONE IS AN ANTICONVULSANT.

22
Q

Treatment for Catamenial seizures

A

ACETAZOLAMIDE

23
Q

Agents of choice for a pregnant woman with epilepsy

A

LAMOTRIGINE and Levetiracetam

24
Q

In Eclampsia, agent used?

25
Q

For refractory seizures in focal seizures

A

Lobectomy
Hemisphererectomy

26
Q

In psychological seizures

A

SERTRALINE

27
Q

In psychological seizures

A

SERTRALINE

Mnemonics (8 decks)

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