Epilepsy drug toxicity

Question 1

Benzo (3)

Answer 1

Sedation, tolerance, dependence

Question 2

Carbamazepine (9)

Answer 2

agranulosytosis, aplastic anemia, ataxia, diplopia, liver, teratogen, induction of P450, SIADH, SJS (9)

Question 3

Ethosuzimide (5)

Answer 3

GI, fatigue, headache, urticaria, SJS

EGFH
“ethosuximide, fatigue, GI, headache”

Question 4

Phenobarbital (4)

Answer 4

Sedation, tolerance, dependence, induction of cyt 450

Question 5

Phenytoin (13)

Answer 5

Nystagmus, diplopia, ataxia, sedation, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogen, SLE, induction of p450, LAD, SJS, osteopenia

Question 6

Valproic acid (5)

Answer 6

GI stress, rare but fatal hepatotoxicity (measure LFT), neural tube defects in fetus (spina bifida), tremor, weight gain
Contraindicated in pregnancy

Question 7

Lamotrigine

Answer 7

SJS

Question 8

Gabepentin (2)

Answer 8

Sedation, ataxia

Question 9

Topiramate (4)

Answer 9

Sedation, mental dulling, kidney stone, weight loss