Epilepsy

Question 1

What drug reverses Midazolam overdose?

Answer 1

Flumazenil

Question 2

What conditions need to be met to be classed as epilepsy?

Answer 2

At least 2 unprovoked or reflex seizures occurring more than 24hrs apart

One unprovoked or reflex seizure and a probability of further seizure similar to general reccurrence risk (at least 60percent) after 2 unprovoked seizure, occurring over the next 10yrs

Question 3

What drugs can cause seizure?

Answer 3

Chloroquine
Bupropion
Tricyclic antidepressants
Quinolones
Antipsychotics
Tramadol
Pethidine

Question 4

What anti epileptic drugs reduce COC/POP?

Answer 4

Carbamazepine
Phenytoin
Topiramate (if more than 200mg/day)

Question 5

What effective contraception is advised for women taking anti epileptic drugs that afftec COC/POC?

Answer 5

Depo-provera
IUD/IUS
High dose oestrogen pills (at least 50mcg+trocycling with a 4 day pill free period only)

Question 6

Most anti epileptic drugs are given BD. However, some can be given OD. Which drugs can be given OD?

Answer 6

Phenobarbital (on)
Lamotrigine
Perampanel
Phenytoin

Question 7

Anti epileptic drugs that cause blood dyscrasia? What to monitor

Answer 7

Carbamazepine
Phenytoin
Lamotrigine
Valproate
Etgosuximide
Topiramate
Zonisamide

Infection, bruising or bleeding

Question 8

Drugs that cause eye problems?

Answer 8

Topiramate glaucoma

Vigabatrin visual filed defects

Question 9

Drugs that cause encephalopathic symptoms?

Answer 9

Vigabatrin marked sedation and confusion

Slow wave EEG