Epilepsy

Question 1

Phenytoin

Answer 1

Na channel blocker

Question 2

Carbamazepine

Answer 2

Na channel blocker

Question 3

Lamotrigine

Answer 3

Ca channel blocker

Question 4

Valproate

Answer 4

Ca channel blocker

Question 5

Valproate

Answer 5

First line- acts on all 3 receptor systems
Na channel blocker
Ca channel blocker
Inhibits Gaba transaminase and succinic acid semialdehyde dehydrogenase

Question 6

Topiramate

Answer 6

Na channel blocker
Also increases GABA neurotransmission

Question 7

Phenobarbital

Answer 7

Agonist of GABA a receptor and PAM.
ALSO blocks Na channels
For fever convulsions in neonates and young children

Question 8

Tiagabine

Answer 8

Selective GABA reuptake inhibitor

Question 9

Vigabatrin

Answer 9

IRREVERSSİBLE inhibitor of gaba transaminase
Causes irreversible Gaba transaminase inhibition

Question 10

Gabapentin

Answer 10

Selective gaba reuptake inhibitor
Used as an add on theraphy for focal seizures

Question 11

Pregabalin

Answer 11

Selective gaba reuptake inhibitor
Used as an add on therapy for focal seizures
Both pregabalin and gabapentin have risk of abuse and increases suicidal tendencies
Can also be used for neurophathic pain

Question 12

Ethosuximide

Answer 12

For petit-mal epilepsy
May cause gastric mucosa irritation
IS NOT BOUND to plasma proteins
Use enteric-coated tablets

Question 13

Levatiracetam
Brivaracetam

Answer 13

ADD ON FOR focal seizures with or without generalization
Very little chance of interactions- it is a substrate of CYP2C9.
Side effects: Diziness, anesthesia

Question 14

Locosamide

Answer 14

Voltage gated na channel blocker
Only a very strong cyp inducer like rifampin may effect the plasmid levels of locosamide