ADHD Drugs

Question 1

Amphetamines

Answer 1

Party drug, weight loss drug, prior drugs for treatment of narcolepsy and ADHD.

Question 2

Modafinil

Answer 2

Narcolepsy treatment

Question 3

METHYLPHENIDATE
What is it, what does şt do? Bioavailability and side effects?

Answer 3

Ritalin
ADHD and narcolepsy treatment
Blocks dopamine and noradrenaline uptake.
Bioavalibility: T1/2 = 2-4 HRS
SIDE EFFECTS: insomnia, decreased appetite, emotional unstability, (dose dependent and dissappear during course of therapy), maybe cardiobascular problems

Question 4

Dexamphetamine(only in magistral preparations)

Answer 4

Alternative for methylphenidate

Question 5

Atomoxetine

Answer 5

Antidepressant, NA uptake inhibitor, for adhd treatment.
No central stimulating effects, increased suicide risk
T1/2 = 5HR= 24 HOUR ACTION
Less side effects than ritaline

Question 6

Fenethylline

Answer 6

Pro-drug- ritalin like

Question 7

More alternatives than dexamphetamine?

Answer 7

TCA’S= desipromine
Clonidine= moderate effect in ADHD symptoms

Question 8

ADHD contraversies

Answer 8

Ethical issues, effect on dopaminergic transmission: addiction,
Influence of der? Omega3 fatty acids