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Drug Target Identification and Evaluation > Epigenetics crash course > Flashcards

Epigenetics crash course Flashcards

1
Q

How can histones be covalently modified?

A
  • methylation
  • acetylation
  • phosphorylation
  • ubiquitilation
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2
Q

Acetylation of histone lysine residues

A

increases transcription (DNA is not as tightly bound anymore)

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3
Q

Methylation of H3K4

A

promotes activation

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4
Q

Methylation of H3K9

A

promotes repression

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5
Q

Where does DNA methylation often occur?

A

At CpG islands

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Drug Target Identification and Evaluation (15 decks)

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