epidermolysis bullosa acquisita

Question 1

Achronicsubepidermalbullousdiseaseassociatedwithautoimmunitytoth

Answer 1

type 7 collagen

Question 2

what type of eba…. is a nonin ammatory, blistering eruption with acral distribution that heals with scarring and milia ormation. It is a mechanobullous disease marked by skin
ragility.Scarsintraumatizedregionssuchasthedorsao thehands,knuckles,elbows,knees,sacral area, and toes. Resembling porphyria cutanea tarda (see Section 10) or hereditary epidermolysis bullosa.

Answer 2

classic mechanobullous presentation

Question 3

Widespreadin ammatoryvesiculobullouseruptionassoci- atedwitherythematousorurticarialskinlesionsinvolvingthetrunk,skin olds,andinadditionthe extremities

Answer 3

Bullouspemphigoid–likepresentation

Question 4

hasprominentmucosalinvolvement—erosionsandscarring in the mouth, esophagus, conjunctiva, anus, and vagina

Answer 4

Cicatricialpemphigoid–likepresentation

Question 5

shows vesicles arranged in an annular ashion, reminiscento linearIgAbullousdermatosis,DH,orCBDC

Answer 5

The linear IgAbullous dermatosis–like presentation

Question 6

histo

Answer 6

Subepidermal blisters

Question 7

IP

Answer 7

linearIgG(plusIgA,gM, actorB,andproperdin)atthedermal–epidermaljunction.
■ Antibodiesinserabindtoa290-kDabandinWesternblotscontainingtypeVIIcollagen.ELISA
speci c or antibodies to type VIIcollagen.

Question 8

tx

Answer 8

SomeEBApatientsimproveondapsoneandhigh doseso colchicine.Supportivetherapy